Abstract
The human immunodeficiency virus type 1 (HIV-1) is the etiologic agent of the acquired immunodeficiency disease syndrome (AIDS). Transcription of HIV-1 is regulated by the virally encoded trans-activator, Tat (Varmus, 1988; Cullen and Greene, 1989; Jones 1989; Sharp and Marciniak, 1989; Pavlakis and Felber, 1990). Tat acts at the 5′ LTR to greatly increase levels of viral RNA and proteins (Rosen et al, 1985; Peterlin et al, 1986; Muessing et al., 1987). Tat has been shown to be essential for efficient viral replication and cytopathology (Dayton et al., 1986; Fisher et al., 1986).
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© 1991 Plenum Press, New York
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Selby, M.J., Peterlin, B.M. (1991). HIV-1 Tat trans-activates in the Absence of its Target. In: Kumar, A. (eds) Advances in Molecular Biology and Targeted Treatment for AIDS. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5928-9_11
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DOI: https://doi.org/10.1007/978-1-4684-5928-9_11
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