HIV-1 Tat trans-activates in the Absence of its Target

  • Mark J. Selby
  • B. Matija Peterlin
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


The human immunodeficiency virus type 1 (HIV-1) is the etiologic agent of the acquired immunodeficiency disease syndrome (AIDS). Transcription of HIV-1 is regulated by the virally encoded trans-activator, Tat (Varmus, 1988; Cullen and Greene, 1989; Jones 1989; Sharp and Marciniak, 1989; Pavlakis and Felber, 1990). Tat acts at the 5′ LTR to greatly increase levels of viral RNA and proteins (Rosen et al, 1985; Peterlin et al, 1986; Muessing et al., 1987). Tat has been shown to be essential for efficient viral replication and cytopathology (Dayton et al., 1986; Fisher et al., 1986).


Human Immunodeficiency Virus Coat Protein Efficient Viral Replication LexA Binding Site Acquire Immunodeficiency Disease Syndrome 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Mark J. Selby
    • 1
  • B. Matija Peterlin
    • 1
  1. 1.Howard Hughes Medical Institute and Departments of Medicine, Microbiology and ImmunologyUniversity of California at San FranciscoSan FranciscoUSA

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