HIV-1 Tat trans-activates in the Absence of its Target
The human immunodeficiency virus type 1 (HIV-1) is the etiologic agent of the acquired immunodeficiency disease syndrome (AIDS). Transcription of HIV-1 is regulated by the virally encoded trans-activator, Tat (Varmus, 1988; Cullen and Greene, 1989; Jones 1989; Sharp and Marciniak, 1989; Pavlakis and Felber, 1990). Tat acts at the 5′ LTR to greatly increase levels of viral RNA and proteins (Rosen et al, 1985; Peterlin et al, 1986; Muessing et al., 1987). Tat has been shown to be essential for efficient viral replication and cytopathology (Dayton et al., 1986; Fisher et al., 1986).
KeywordsHuman Immunodeficiency Virus Coat Protein Efficient Viral Replication LexA Binding Site Acquire Immunodeficiency Disease Syndrome
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