The Effects of Canthaxanthin on JB/MS Melanoma Growth During Retroviral Pathogenesis Induced by LP-BM5 Murine Leukemia Virus
AIDS (Acquired Immune Deficiency Syndrome) is the end stage of disease initiated in man by infection with HIV-1 (Human Immunodeficiency Virus) and related viruses. Progression from retroviral infection to AIDS can take years, and may be influenced by immunosuppressive cofactors including drugs of abuse (1,2) and immunostimulatory ones like nutrients (3,4). The role of such compounds in progression to AIDS is difficult to study in humans because of ethical, economical and logistical considerations. While HIV infection has been possible in chimpanzees, it has produced little pathogenesis (6). To investigate simultaneously the effects of immunostimulatory compounds and retroviral infection, it would be advantageous to use a non-primate model.
KeywordsInfected Mouse Immune Deficiency Syndrome Flat Bottom Tissue Culture Plate Profound Immunosuppression Bottom Tissue Culture Plate
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- 1.R. R. Watson, Immunomodulation by Alcohol: A Cofactor in Development of AIDS After Retrovirus Infection, in: “Cofactors in HIV-I Infection and AIDS,” CRC Press (1989).Google Scholar
- 2.R. R. Watson and C. L. Wallace, Drugs of Abuse as Cofactors in the Progression of HIV Infection to AIDS, in: “Cofactors in HIV-1 Infection and AIDS,” CRC Press (1989).Google Scholar
- 3.T. K. Leonard-Green and R. R. Watson, The AIDS-Immunocompetence-Nutrition Infection Cycle, in: “Cofactors in HIV-I Infection and AIDS,” CRC Press (1989).Google Scholar
- 6.L. A. Salzman, “Animal Models of Retrovirus Infection and Their Relationship to AIDS,” Academic Press (1986).Google Scholar
- 13.S. P. Klinken, T. N. Fredrickson, J. W. Hartley, R. A. Yetter, and H. C. Morse III, Evaluation of B cell lineage lymphomas in mice with a retrovirus-induced immunodeficiency syndromes, MAIDS, J. Immunol. 140: 1123 (1988).Google Scholar
- 14.M. I. Luster, A. E. Munson, P. T. Thomas, M. P. Holsapple, J. D. Fenters, K. L. White Jr., L. D. Lauer, D. R. Germolee, G. J. Rosenthal, and J. H. Dean, Development of a testing battery to assess chemical-induced im-munotoxicity: National toxicology program’s guidelines for immunotoxicity evaluation in mice, Fundamental Appl. Toxicol. 10:2 (1988).CrossRefGoogle Scholar
- 20.E. R. Abril, J. A. Rybski, P. Scuderi, and R. R. Watson, Beta-carotene stimulates human monocyte secretion of a novel tumoricidal cytokine, J. Leuk. Biol. 45:255 (1989).Google Scholar
- 21.R. R. Watson and J. Rybski, Immunological response modification by vitamin A and other retinoids, in: “Nutrition and Immunology,” R. K. Chandra, ed., A. R. Liss, New York (1988).Google Scholar
- 22.M. J. Murray, et al., Models for the evaluation of tumor resistance following chemical or drug exposure, Immunotoxicology and Immunopharmacology113 (1985).Google Scholar
- 25.T. E. Moon and M. S. Micozzi, Beta-carotene, canthaxanthin, and phytoene, Nutr. Cancer Prev. 273 (1989).Google Scholar