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The Effects of Ethanol, Tumor Necrosis Factor, and Granulocyte Colony-Stimulating Factor on Lung Antibacterial Defenses

  • Steve Nelson
  • Gregory Bagby
  • Jeff Andresen
  • Chester Nakamura
  • Judd Shellito
  • Warren Summer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 288)

Abstract

Respiratory tract infections are major causes of morbidity and mortality in individuals abusing alcohol (1). Sir William Osler, in his Principles and Practice of Medicine, stated that alcoholism was “perhaps the most potent predisposing factor” to bacterial pneumonia (2). Since this early observation, numerous other clinical investigations have reported evidence that alcoholics are at increased risk for severe pneumonia (3, 4). Despite recent technologic advances in the management of these infections and ever more “potent” antibiotics, there has been little decline in the mortality associated with this disease in alcohol consuming patients.

Keywords

Host Defense Alveolar Macrophage Acute Alcohol Intoxication Bronchial Lavage Antibacterial Defense 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Steve Nelson
    • 1
  • Gregory Bagby
    • 1
  • Jeff Andresen
    • 2
  • Chester Nakamura
    • 1
  • Judd Shellito
    • 1
  • Warren Summer
    • 1
  1. 1.Departments of Medicine and PhysiologyLouisiana State University Medical CenterNew OrleansUSA
  2. 2.Amgen, Inc.Thousand OaksUSA

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