The Effects of Ethanol, Tumor Necrosis Factor, and Granulocyte Colony-Stimulating Factor on Lung Antibacterial Defenses
Respiratory tract infections are major causes of morbidity and mortality in individuals abusing alcohol (1). Sir William Osler, in his Principles and Practice of Medicine, stated that alcoholism was “perhaps the most potent predisposing factor” to bacterial pneumonia (2). Since this early observation, numerous other clinical investigations have reported evidence that alcoholics are at increased risk for severe pneumonia (3, 4). Despite recent technologic advances in the management of these infections and ever more “potent” antibiotics, there has been little decline in the mortality associated with this disease in alcohol consuming patients.
KeywordsHost Defense Alveolar Macrophage Acute Alcohol Intoxication Bronchial Lavage Antibacterial Defense
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