Effect of Prenatal Alcohol Exposure on Lymphocyte Populations in Mice

  • Sandra J. Ewald
  • Ching Huang
  • Laura Bray
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 288)


The effect of prenatal alcohol exposure on the immune system remains a relatively unexplored area of research. In humans, children diagnosed with fetal alcohol syndrome (FAS) have been reported to be immune-deficient with respect to both T-and B-lymphocytes (1,2). Given that factors such as protein malnutrition (3) or zinc deficiency (4) can have profound effects on the developing immune system, and the known association of alcoholism with poor nutrition, it is important to use animal models in which nutrition as well as other variables can be controlled. The mouse has been used as a model of prenatal alcohol exposure by teratologists for a number of years (5,6). Furthermore, mice are well-characterized immunologically. We have therefore used a mouse model of prenatal ethanol exposure, in which pregnant C57BL/6 mice are fed a complete liquid diet containing ethanol.


Fetal Alcohol Syndrome Prenatal Alcohol Exposure Surrogate Mother Fetal Thymus Prenatal Ethanol Exposure 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Sandra J. Ewald
    • 1
  • Ching Huang
    • 1
  • Laura Bray
    • 1
  1. 1.Department of MicrobiologyMontana State UniversityBozemanUSA

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