Abstract
The effect of prenatal alcohol exposure on the immune system remains a relatively unexplored area of research. In humans, children diagnosed with fetal alcohol syndrome (FAS) have been reported to be immune-deficient with respect to both T-and B-lymphocytes (1,2). Given that factors such as protein malnutrition (3) or zinc deficiency (4) can have profound effects on the developing immune system, and the known association of alcoholism with poor nutrition, it is important to use animal models in which nutrition as well as other variables can be controlled. The mouse has been used as a model of prenatal alcohol exposure by teratologists for a number of years (5,6). Furthermore, mice are well-characterized immunologically. We have therefore used a mouse model of prenatal ethanol exposure, in which pregnant C57BL/6 mice are fed a complete liquid diet containing ethanol.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
S. Johnson, R. Knight, D. J. Marmier, and R. W. Steele, Immune deficiency in fetal alcohol syndrome, Pediatr. Res. 15:908 (1981).
M. Calvani, D. Ghirelli, and C. Fortuna, Fetal alcohol syndrome: clinical, metabolic and immunologic follow-up in 14 cases, Minerva Pediatr. 37:77 (1985).
R. K. Chandra, Fetal malnutrition and postnatal immunocompetence, Am. J. Dis. Child. 129:450 (1975).
R. S. Beach, M.E. Gershwin, R.K. Makishima, and L.S. Hurley, Impaired immunologic ontogeny in postnatal zinc deprivation, J. Nutr. 110:805 (1980).
G. F. Chernoff, The fetal alcohol syndrome in mice: An animal model, Teratology 15:223 (1977).
C. L. Randall and W. J. Taylor, Prenatal ethanol exposure in mice: teratogenic effects, Teratology 19:305 (1979).
Y. Eishi, K. Hirokawa, and S. Hatakeyama, Long-lasting impairment of immune and endocrine systems of offspring induced by injection of dexametha-sone into pregnant mice, Clin. Immunol. Immunopathol. 26:335 (1983).
S. J. Ewald and S.M. Waiden, Flow cytometric and histological analysis of mouse thymus in fetal alcohol syndrome, J. Leuk. Biol. 44:434 (1988).
T. -Y. Ha, N. D. Reed, and P. K. Crowle, Immune response potential of mast cell-deficient W/Wv mice, Int. Archs Allergy appl. Immunol. 80:85 (1986).
R. H. Zidell, N. S. Hatoum, and P. T. Thomas, Fetal Alcohol Effects: Evidence of developmental impairment in the absence of immunotoxicity, Fund. Appl. Toxicol. 10:189 (1988).
J. A. Harp and S. J. Ewald, Modulation of in vitro immune responses by monoclonal antibody to T200 antigen, Cell. Immunol. 81:71 (1983).
J. A. Harp, B. S. Davis, and S. J. Ewald, Inhibition of T cell responses to alloantigens and polyclonal mitogens by Ly-5 antisera. J. Immunol. 133:10 (1984).
R. Ceredig, Differentiation potential of 14-day fetal mouse thymocytes in organ culture. Analysis of CD4/CD8-defined single-positive and double-negative cells, J. Immunol. 141:355 (1988).
S. J. Ewald and W. W. Frost, Effect of prenatal exposure to ethanol on development of the thymus, Thymus 9:211 (1987).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Plenum Press, New York
About this chapter
Cite this chapter
Ewald, S.J., Huang, C., Bray, L. (1991). Effect of Prenatal Alcohol Exposure on Lymphocyte Populations in Mice. In: Friedman, H., Specter, S., Klein, T.W. (eds) Drugs of Abuse, Immunity, and Immunodeficiency. Advances in Experimental Medicine and Biology, vol 288. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5925-8_27
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5925-8_27
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5927-2
Online ISBN: 978-1-4684-5925-8
eBook Packages: Springer Book Archive