Effects of Morphine Addiction on the Pathogenesis of Murine Toxoplasmosis
Intravenous (IV) opiate use has been known, for at least 40 years, to be associated with a markedly increased morbidity and mortality due to infectious diseases (1). The identification of opiate-mediated immune defects has led to the proposal that these abnormalities may play a role in the pathogenesis of certain infections (2,3). While there are numerous studies demonstrating the effects of opiates on immune functions in vitro, few studies provide convincing data regarding the biological significance of these findings as they may relate to host resistance to infectious agents (4–7).
KeywordsPlacebo Morphine Encephalitis Toxoplasmosis Sulfadiazine
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