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Effects of Morphine Addiction on the Pathogenesis of Murine Toxoplasmosis

  • Chun C. Chao
  • Burt M. Sharp
  • Claire Pomeroy
  • Gregory A. Filice
  • Phillip K. Peterson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 288)

Abstract

Intravenous (IV) opiate use has been known, for at least 40 years, to be associated with a markedly increased morbidity and mortality due to infectious diseases (1). The identification of opiate-mediated immune defects has led to the proposal that these abnormalities may play a role in the pathogenesis of certain infections (2,3). While there are numerous studies demonstrating the effects of opiates on immune functions in vitro, few studies provide convincing data regarding the biological significance of these findings as they may relate to host resistance to infectious agents (4–7).

Keywords

Toxoplasma Gondii Morphine Administration Morphine Sulfate Toxoplasmic Encephalitis Hennepin County 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Chun C. Chao
    • 1
    • 2
    • 3
  • Burt M. Sharp
    • 1
    • 2
    • 3
  • Claire Pomeroy
    • 1
    • 2
    • 3
  • Gregory A. Filice
    • 1
    • 2
    • 3
  • Phillip K. Peterson
    • 1
    • 2
    • 3
  1. 1.Department of MedicineHennepin County Medical Center and the Minneapolis Medical Research FoundationMinneapolisUSA
  2. 2.Department of MedicineVA Medical CenterMinneapolisUSA
  3. 3.University of Minnesota Medical SchoolMinneapolisUSA

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