Endorphin Peptides Enhance Mitogen-Induced T Cell Proliferation Which has been Suppressed by Prostaglandins
The endogenous 31-amino acid peptide β-endorphin has been reported to both increase (1–6) and suppress (7,8) mitogen-induced T lymphocyte proliferation. No effect of β-endorphin on B cell proliferation has been noted (2). However, β-endorphin has been shown to decrease antibody production as measured by the plaque-forming cell response (5,9). These results suggest that β-endorphin may inhibit immunoglobulin synthesis by modulating T cell function.
KeywordsLymphocyte Proliferation Thymidine Uptake Spleen Cell Proliferation Differ Amino Acid Enhance Lymphocyte Proliferation
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