Endorphin Peptides Enhance Mitogen-Induced T Cell Proliferation Which has been Suppressed by Prostaglandins

  • Lucinda M. Hemmick
  • Jean M. Bidlack
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 288)


The endogenous 31-amino acid peptide β-endorphin has been reported to both increase (1–6) and suppress (7,8) mitogen-induced T lymphocyte proliferation. No effect of β-endorphin on B cell proliferation has been noted (2). However, β-endorphin has been shown to decrease antibody production as measured by the plaque-forming cell response (5,9). These results suggest that β-endorphin may inhibit immunoglobulin synthesis by modulating T cell function.


Lymphocyte Proliferation Thymidine Uptake Spleen Cell Proliferation Differ Amino Acid Enhance Lymphocyte Proliferation 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Lucinda M. Hemmick
    • 1
  • Jean M. Bidlack
    • 1
  1. 1.Department of Pharmacology, School of Medicine and DentistryUniversity of RochesterRochesterUSA

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