Opiates as Immunosuppressive and Genotoxic Agents

  • Arthur Falek
  • Robert M. Donahoe
  • John J. Madden
  • David A. Shafer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 288)


From a historical prospective our immunologic investigations started as a natural consequence of our findings that opiates reduced the genetic integrity of human lymphocytes indicated by evidence of an increased frequency of chromosome damage and a deficiency in DNA repair capacity. Such changes in genetic structure and function are expected to indicate mutagenic and/or carcinogenic outcomes (1).


Acquire Immune Deficiency Syndrome Sister Chromatid Exchange Opiate Receptor Chromosome Damage Sulphur Mustard 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Arthur Falek
    • 1
  • Robert M. Donahoe
    • 1
    • 2
  • John J. Madden
    • 1
  • David A. Shafer
    • 1
  1. 1.Human and Behavior Genetics Laboratory, Department of PsychiatryEmory University GMHIAtlantaUSA
  2. 2.Psychoimmunology Laboratory, Department of PsychiatryEmory University GMHIAtlantaUSA

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