In vitro Effect of High Doses of Morphine on Con a Induced Lymphokine Production

  • John J. Jessop
  • Michael S. Taplits
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 288)


Opiate addicts are often exposed to doses of exogenous opiates as high as 2 grams of heroin per day (1). Opiates also concentrate in the spleen, thus exposing the cells of the immune system in addicts to high concentrations of these drugs (2). As a possible consequence of this, IV drug users are immunosup-pressed (3,4), causing them to be more susceptible to a variety of diseases including AIDS, a devastating illness which affects a significant percent of this population.


Opiate Receptor Beta Endorphin Opiate Antagonist Morphine Concentration Opiate Agonist 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • John J. Jessop
    • 1
  • Michael S. Taplits
    • 1
  1. 1.Center for Biologics Evaluation and Research, Division of Blood and Blood Products, Laboratory of Cell BiologyU.S. Food and Drug AdministrationBethesdaUSA

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