Advertisement

In vitro Effect of High Doses of Morphine on Con a Induced Lymphokine Production

  • John J. Jessop
  • Michael S. Taplits
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 288)

Abstract

Opiate addicts are often exposed to doses of exogenous opiates as high as 2 grams of heroin per day (1). Opiates also concentrate in the spleen, thus exposing the cells of the immune system in addicts to high concentrations of these drugs (2). As a possible consequence of this, IV drug users are immunosup-pressed (3,4), causing them to be more susceptible to a variety of diseases including AIDS, a devastating illness which affects a significant percent of this population.

Keywords

Opiate Receptor Beta Endorphin Opiate Antagonist Morphine Concentration Opiate Agonist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    R. Zandomeneghi, A. Luciani, M. Massari, P. Montanari, and C. Pavesi, Effects of heroin addiction on the responses of glucose, C-peptide and insulin to a standard meal, Clin. Sci. 74(3):283 (1988).PubMedGoogle Scholar
  2. 2.
    A. E. Robinson and F. M. Williams, The distribution of methadone in man, J. Pharm. Pharmacol. 23:353 (1970).CrossRefGoogle Scholar
  3. 3.
    S. M. Brown, B. Stimmel, R. N. Taub, S. Kochwa, and R. E. Rosenfield, Immunologic dysfunction in heroin addicts, Arch. Intern. Med. 134:1001 (1974).PubMedCrossRefGoogle Scholar
  4. 4.
    R. J. McDonough, J. J. Madden, A. Falek, D. A. Shafer, M. Pline, D. Gordon, P. Bokos, J. C. Kuehnle, and J. Mendelson, Alteration of T and null lymphocyte frequencies in the peripheral blood of human opiate addicts: in vivo evidence for opiate receptor sites on lymphocytes, Journalof Immunology 125(6):2539 (1980).Google Scholar
  5. 5.
    Y. Shavit, J. W. Lewis, G. W. Terman, R. P. Gale, and J. C. Liebeskind, Endogenous opioids may mediate the effects of stress on tumor growth and immune function, Proc. West. Pharmacol. Soc. 26:53 (1983).PubMedGoogle Scholar
  6. 6.
    Y. Shavit, J. W. Lewis, G. W. Terman, R. P. Gale, and J. C. Liebeskind, Opioid peptides mediate the suppressive effect of stress on natural killer cell cytotoxicity, Science 223:188 (1984).PubMedCrossRefGoogle Scholar
  7. 7.
    H. U. Bryant, E. W. Bernton, and J. W. Holaday, Immunosuppressive effects of chronic morphine treatment in mice, Life Sciences 41(14):1732 (1987).CrossRefGoogle Scholar
  8. 8.
    H. U. Bryant, E. W. Bernton, and J. W. Holaday, Morphine pellet-induced immunomodulation in mice: temporal relationships, JPET 245(3):913 (1988).Google Scholar
  9. 9.
    Y. Shavit, A. Depaulis, F. C. Martin, G. W. Terman, R. N. Pechnich, C. J. Zane, R. P. Gale, and J. C. Liebeskind, Involvement of brain opiate receptors in the immune-suppressive effect of morphine, Proc. Natl. Acad. Sd. 83:7114 (1986).CrossRefGoogle Scholar
  10. 10.
    Y. Asano and R. J. Hodes, T cell regulation of B cell activation. Cloned Lyt-1+2T suppressor cells inhibit the major histocompatibility complex-restricted interaction of T helper cells with B cells and/or accessory cells, J. Exp. Med. 158:1178 (1983).PubMedCrossRefGoogle Scholar
  11. 11.
    S. Gillis, M. M. Ferm, W. Ou, and K. A. Smith, T cell growth factor; parameters of production and quantitative microassay for activity, J. Immunol. 120:2027 (1978).PubMedGoogle Scholar
  12. 12.
    M. V. Sitkovsky, M. S. Pasternack, L. P. Lugo, J. R. Klein, and H. A. Eisen, Isolation and partial characterization of concanavalin A receptors on cloned cytotoxic T lymphocytes, Proc. Natl. Acad. Sci. USA 81:1519 (1984).PubMedCrossRefGoogle Scholar
  13. 13.
    H. U. Bryant, T. K. Shakarjian, E. W. Bernton, and J. W. Holaday, Morphine-induced immunosuppression in mice: effects of naloxone and morphine tolerance, Pharmacologist 29:106 (1987).Google Scholar
  14. 14.
    J. J. Jessop, G. L. West, and T. J. Sobotka, Immunomodulatory effects of footshock in the rat, Journal of Neuroimmunology 25:241 (1989).PubMedCrossRefGoogle Scholar
  15. 15.
    V. K. Singh, A. Jakubovic, and D. A. Thomas, Suppressive effects of methadone on human blood lymphocytes, Immunology Letters 2:177 (1980).CrossRefGoogle Scholar
  16. 16.
    G. Bocchini, G. Bonanno, and A. Canevari, Influence of morphine and naloxone on human peripheral blood T lymphocytes, Drug and Alcohol Dependence 11:233 (1983).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • John J. Jessop
    • 1
  • Michael S. Taplits
    • 1
  1. 1.Center for Biologics Evaluation and Research, Division of Blood and Blood Products, Laboratory of Cell BiologyU.S. Food and Drug AdministrationBethesdaUSA

Personalised recommendations