Effects of Cocaine and Other Drugs of Abuse on Immune Function

  • Robert M. Donahoe
  • Arthur Falek
  • John J. Madden
  • Janet K. A. Nicholson
  • Peter Bokos
  • Karl Gallegos
  • Richard Veit
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 288)


Approximately 19 years ago, Falek et al. (1) reported that heroin addicts frequently exhibit abnormally high levels of cytogenetic damage in their T-lymphocytes after mitogenic stimulation in vitro with the plant lectin, phytohemag-glutinin. Later, Madden et al. (2) showed that this damage was probably due to altered DNA-repair capacity of lymphocytes. Less obvious, perhaps, than the genetic implications of these findings were their immunological implications, which, in fact, were significant.


Opiate Receptor Cocaine Abuse Heroin Addict Heroin Abuse Opiate Addict 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Robert M. Donahoe
    • 1
    • 2
  • Arthur Falek
    • 2
  • John J. Madden
    • 2
  • Janet K. A. Nicholson
    • 3
  • Peter Bokos
    • 4
  • Karl Gallegos
    • 5
  • Richard Veit
    • 5
  1. 1.Laboratory of PsychoimmunologyEmory University, GMHIAtlantaUSA
  2. 2.Department of PsychiatryEmory UniversityUSA
  3. 3.Division of Host FactorsCenters for Disease ControlAtlantaUSA
  4. 4.Interventions, IncorporatedChicagoUSA
  5. 5.Georgia Alcohol and Drug AssociatesAtlantaUSA

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