Combined Immunosuppressive Activities of Delta-9-Tetrahydrocannabinol and Murine Retrovirus
The progression of events from initial infection with human immunodeficiency virus (HIV) resulting in the development of the acquired immunodeficiency syndrome (AIDS) has stimulated a myriad of studies to identify cofactors capable of promoting HIV replication, thereby hastening the development of overt disease. One group of substances that has been touted as possible candidate cofactors in the progression of AIDS is drugs of abuse (1). The inability to study these virus-drug interactions in humans has generated the need for animal models to examine the effects of drugs of abuse on retrovirus replication and infection. The use and validity of particular animal infections on models for AIDS in man have been the subject of inquiry and debate (2–5). One useful experimental system employs the murine retrovirus, Friend leukemia virus (FLV) (6).
KeywordsHuman Immunodeficiency Virus Spleen Cell Natural Killer Cell Activity Herpes Simplex Virus Infection Lymphocyte Blastogenesis
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