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Combined Immunosuppressive Activities of Delta-9-Tetrahydrocannabinol and Murine Retrovirus

  • Steven Specter
  • Gerald Lancz
  • Gina Westrich
  • Herman Friedman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 288)

Abstract

The progression of events from initial infection with human immunodeficiency virus (HIV) resulting in the development of the acquired immunodeficiency syndrome (AIDS) has stimulated a myriad of studies to identify cofactors capable of promoting HIV replication, thereby hastening the development of overt disease. One group of substances that has been touted as possible candidate cofactors in the progression of AIDS is drugs of abuse (1). The inability to study these virus-drug interactions in humans has generated the need for animal models to examine the effects of drugs of abuse on retrovirus replication and infection. The use and validity of particular animal infections on models for AIDS in man have been the subject of inquiry and debate (2–5). One useful experimental system employs the murine retrovirus, Friend leukemia virus (FLV) (6).

Keywords

Human Immunodeficiency Virus Spleen Cell Natural Killer Cell Activity Herpes Simplex Virus Infection Lymphocyte Blastogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    R. R. Watson, “Drugs of Abuse and Immune Function,” CRC Press, Orlando (1990).Google Scholar
  2. 2.
    M. B. Gardner and P. A. Lucin, Animal Models for AIDS, The FASEB Journal3:2593 (1989).Google Scholar
  3. 3.
    R. M. Ruprecht, Murine models for antiretroviral therapy, Intervirology 30 (suppl 1):2 (1989).PubMedGoogle Scholar
  4. 4.
    L. A. Salzman, “Animal Models of Retrovirus Infection and their Relationship to AIDS,” Academic Press, Orlando (1986).Google Scholar
  5. 5.
    S. Specter, M. Bendinelli, and H. Friedman, “Virus-Induced Immuno-suppression,” Plenum Press, New York City (1989).Google Scholar
  6. 6.
    E. Soldaini, D. Mateucci, M. Lopez-Cepero, S. Specter, H. Friedman, and M. Bendinelli, Friend leukemia complex infection of mice as an experimental model for AIDS studies, Vet. Immunol. Immunopathol. 21:97 (1989).PubMedCrossRefGoogle Scholar
  7. 7.
    S. Specter, F. Basolo, and M. Bendinelli, Tetroviruses as immunosuppressive agents, in: “The Nature, Cellular, and Biochemical Basis and Management of Immunodeficiencies,” R. A. Good and E. Lindenlaub, eds., F. K. Schattauer Verlag, Stuttgart (1987).Google Scholar
  8. 8.
    D. J. Moody, S. Specter, M. Bendinelli, and H. Friedman, Suppression of natural killer cell activity by Friend murine leukemia virus, J. Natl. Cancer Inst. 72:1349 (1984).PubMedGoogle Scholar
  9. 9.
    M. Lopez-Cepero, S. Specter, D. Mateucci, H. Friedman, and M. Bendinelli, Altered interleukin production during Friend leukemia virus infection, Proc. Soc. Exp. Biol. Med. 188:353 (1988).PubMedGoogle Scholar
  10. 10.
    M. Kitagawa, O. Matsubara, and T. Kasuga, Dynamics of lymphocyte subpopulations in Friend leukemia virus-induced leukemia, Cancer Res. 46:3034 (1986).PubMedGoogle Scholar
  11. 11.
    H. Friedman, T. Klein, and S. Specter, Immunosuppression by marijuana and components, in: “Psychoneuroimmunology II: Immunomodulating Effects of Psychoactive Drugs and Drugs of Abuse,” R. Ader, D. L Felton, and N. Cohen, eds., Academic Press, Orlando (1990).Google Scholar
  12. 12.
    B. E. Juel-Jensen, Cannabis and recurrent herpes simplex, Brit. Med. I. 4:296 (1974).CrossRefGoogle Scholar
  13. 13.
    J. L. Guarisco, M. L. Cheney, F. E. LeJeune, and H. T. Reed, Isolated uvulitis secondary to marijuana use, Laryngoscopy 98:1309 (1988).Google Scholar
  14. 14.
    P. J. Donald, Marijuana smoking possible cause of head and neck carcinoma in young patients, Otolaryngol. Head Neck Surg. 94:517 (1986).PubMedGoogle Scholar
  15. 15.
    F. M. Taylor HI, Marijuana as a potential respiratory tract carcinogen. A retrospective analysis of a community hospital population, South Med. J. 81:1213 (1988).PubMedCrossRefGoogle Scholar
  16. 16.
    S. C. Specter, T. W. Klein, C. Newton, M. Mondragon, R. Widen, and H. Friedman, Marijuana effects on immunity: Suppression of human natural killer cell activity by delta-9-tetrahydrocannabinol, Int. J. Immunopharmac. 8:741 (1986).CrossRefGoogle Scholar
  17. 17.
    S. Specter, G. Lancz, and J. Hazelden, Alteration of immune function by marijuana components: Effects on human lymphocyte blastogenesis, Int. J. Immunopharmac. 12:261 (1990).CrossRefGoogle Scholar
  18. 18.
    S. Specter, G. Lancz, and H. Friedman, Marijuana and Immunosuppression in Man, in: “Drugs of Abuse and Immune Functions,” R. R. Watson, ed., CRC Press, Boca Raton (1990).Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Steven Specter
    • 1
  • Gerald Lancz
    • 1
  • Gina Westrich
    • 1
  • Herman Friedman
    • 1
  1. 1.Department of Medical Microbiology and ImmunologyUniversity of South Florida College of MedicineTampaUSA

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