Suppression of T Lymphocyte Subpopulations by THC
THC (delta-9-tetrahydrocannabinol) is considered the major psychoactive component of marijuana. It is widely acknowledged that THC can depress various parameters of the immune response. These parameters include lymphocyte proliferation, macrophage spreading, and antibody production (1–3). Studies have suggested that THC has different magnitudes of effect depending on the lymphoid organ analyzed (2) as well as the age of the animal (4). Different lymphoid organs of adult mice as well as identical organs from mice of various ages have unique proportions of lymphoid cell subpopulations. This study examines the effect of THC on lymphoid cell subpopulations using the lymphoblastogenic assay (LBT) as well as analysis of cell subpopulations by the fluorescent activated cell sorter (FACS).
KeywordsSpleen Cell Fluorescent Activate Cell Sorter Lymphoid Organ Identical Organ Fluorescent Activate Cell Sorter Analysis
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