Advertisement

Cannabinoid Induced Changes in Eicosanoid Synthesis by Mouse Peritoneal Cells

  • Sumner Burstein
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 288)

Abstract

Peritoneal cells, which consist mainly of macrophages, have been extensively studied with regard to their ability to synthesize eicosanoids in response is not entirely understood, however, it has been suggested that it may have a role in macrophage function in the immune system. For some time we have utilized mouse peritoneal cells as a model system in which to study cannabinoid effects on the release of arachidonic acid and its subsequent conversion to certain eicosanoids (1).

Keywords

Arachidonic Acid Pertussis Toxin Peritoneal Cell Plastic Culture Dish Lipoxygenase Product 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    S. Burstein, S. A. Hunter, K. Ozman and L. Renzulli, In vitro models of cannabinoid-induced psychoactivity, Marihuana ’84: Proc. Oxford. Conf. on Cannabis (D. J. Harvey, ed.) pp. 399,1. R. L. Press, Oxford (1985).Google Scholar
  2. 2.
    S. A. Hunter, S. Burstein and C. Sedor, Stimulation of prostaglandin synthesis in WI-38 human lung fibroblasts following inhibition of acylation, Biochim. Biophvs. Acta. 793:202 (1984).Google Scholar
  3. 3.
    J. Axelrod, R. M. Burch and C. J. Jelsema, GTP-binding proteins: arachidonic acid and its metabolites as second messengers, TINS. 11 :117 (1988).PubMedGoogle Scholar
  4. 4.
    S. Burstein, S. A. Hunter, K. Ozman and L. A. Renzulli, Prostaglandins and Cannabis XIII. Cannabinoid induced elevation of lipoxygenase products in mouse peritoneal macrophages, Biochem. Pharmacol. 33:2653 (1984).PubMedCrossRefGoogle Scholar
  5. 5.
    S. Burstein, S. A. Hunter, V. Latham and L. Renzulli, Prostaglandin and Cannabis XVI. Antagonism of ATHC action by its metabolites, Biochem. Pharmacol. 35:2553 (1986).PubMedCrossRefGoogle Scholar
  6. 6.
    S. Burstein, S. A. Hunter, V. Latham and L. Renzulli, A major metabolite of ATHC reduces its cataleptic effect in mice, Experientia 43:402 (1987).PubMedCrossRefGoogle Scholar
  7. 7.
    S. H. Burstein, C. A. Audette, S. A. Doyle, K. Hull, S. A. Hunter and V. Latham, Antagonism to the actions of PAF by a nonpsychoactive cannabinoid, I. Pharmacol. Exp. Therap. 251:531 (1989).Google Scholar
  8. 8.
    J. T. O’Flaherty, J. H. Showell, E. L. Becker and P. A. Ward, Neutrophil aggregation and degranulation. Effect of arachidonic acid, Am. J. Pathol. 95:433 (1970).Google Scholar
  9. 9.
    J. H. Cohen, M. E. Chovaniec, K. Takahashi and J. C. Whitin, Activation of human granulocytes by arachidonic acid; its use and limitations for investigating granulocyte functions, Blood 67:1103 (1986).PubMedGoogle Scholar
  10. 10.
    T. Katada, G. M. Bokoch, M. D. Smigel, M. Ui and A. Gilman, The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase, I. Biol Chem. 259:3586 (1984).Google Scholar
  11. 11.
    M. E. Goldyne, Lymphocytes and arachidonic acid metabolism, in: “Arachi-donate Metabolism in Immunology Systems,” L. Levine, ed., Karger, Basel, New York.Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Sumner Burstein
    • 1
  1. 1.Department of BiochemistryUniversity of Massachusetts Medical SchoolWorcesterUSA

Personalised recommendations