Measurement of Translational Accuracy in Streptomyces
Bacteria as well as eukaryotic cells developed several mechanisms which prevent accumulation of errors in proteins they synthetize. Nevertheless, in both the types of cells the natural level of translational accuracy achieved is far from its attainable maximum since it can be increased by mutations affecting mostly ribosomal proteins. This indicates that a certain optimal level of translational fidelity was selected during evolution rather than its maximum level (Ehrenberg et al., 1986). The reason for this could be that translational errors may play an important regulation role.
KeywordsRibosomal Protein Translational Accuracy Nonsense Suppression Translational Fidelity Mutant Ribosome
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