Advertisement

Population Genetic Processes in Continuously Cultivated Streptomyces Strains Reflect Genetic Instabilities

  • Dieter Noack
  • Rudolf Geuther
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 55)

Abstract

During the last few years the genetic instability of Streptomycetes has been investigated very intensively. The main progress in this field took place since molecular alterations and rearrangements within the chromosomal DNA of these microorganisms have been detected. The study of related phenomena and processes are likely to be important in understanding genome structure and are also important from the commercial point of view as instability can cause strain degeneration and the loss of proficiency to produce antibiotics as well as the loss of resistance against both the strain’s own antibiotics and other ones.

Keywords

Genetic Instability Segregation Kinetic Streptomyces Noursei Population Genetic Process Submerged Mycelium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Geuther, R., Noack, D. and Behnke, D.: An amplifiable unit of DNA emerging from a recombinant Streptomyces plasmid. Poster presented at this symposium.Google Scholar
  2. Gräfe, U., Reinhardt, G. and Noack, D.: Lipid composition of slowly sedimenting chemostat mutants of Streptomyces lividans. Poster presented at this symposium.Google Scholar
  3. Noack, D., Müller, G. and Roth, M.: Mathematical modelling of genetic segregation kinetics obtained with chemostat cultures of procaryotic microorganisms. Z.allg.Mikrobiol. (1984) 24, 459–465.CrossRefGoogle Scholar
  4. Noack, D.: Directed selection of different mutants of Streptomyces noursei using chemostat cultivation. J.Basic Microbiol. (1986) 26, 231–239.PubMedCrossRefGoogle Scholar
  5. Noack, D., Geuther, R., Tonew, M., Breitling, R. and Behnke, D.: Expression and secretion of interferon alpha 1 by Streptomyces lividans-use of staphylokinase signals and amplification of a neo gene. Gene (1988)68, 53–62.Google Scholar
  6. Roth, M.: Use of chemostat for selection of Streptomyces chrysomallus mutants altered in the induction of D-glucoseisomerase. Biotechnol. Letters (1987) 9, 855–860.CrossRefGoogle Scholar
  7. Störl, K., Störl, J. and Zimmer, Ch.: DNA topoisomerases from Streptomyces and their inhibition by some antibiotic and antitumor agents. Lecture presented at this symposium.Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Dieter Noack
    • 1
  • Rudolf Geuther
    • 1
  1. 1.Centralinstitute of Microbiology and Experimental TherapyGDR Academy of SciencesJenaGDR

Personalised recommendations