Presence of Factor C in Streptomycetes and Other Bacteria
Streptomyces have complex life cycle, routes of differentiation. The mycelium contains hyphae representing the vegetative and the reproductive phase of differentiation at the same time. A great deal of observation supports the idea that this differentiation is a highly ordered and genetically determined process. It is relevant that the regulation of morphological differentiation and secondary metabolism are intimately connected. An intriguing example of this relationship is the finding described by Chater’s group1,2 that the reproductive phase and secondary metabolism does not begin in the absence of a particular leu-tRNA reading the rare UUA codon. Considering that antibiotics are the products of the secondary metabolism, the importance of the studies concerning these regulatory processes cannot be overestimated3. A promising field of research is the investigation of those endogenously produced substances (autoregulators) that were shown to influence the differentiation of Streptomyces (A-factor, B-factor, Pamamycin 607, and factor C, reviewed by Szabó et al.4).
KeywordsSecondary Metabolism Neurospora Crassa Reproductive Phase Complex Life Cycle Streptomyces Strain
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