Presence of Factor C in Streptomycetes and Other Bacteria

  • F. Szeszák
  • S. Vitális
  • I. Békési
  • G. Szabó
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 55)


Streptomyces have complex life cycle, routes of differentiation. The mycelium contains hyphae representing the vegetative and the reproductive phase of differentiation at the same time. A great deal of observation supports the idea that this differentiation is a highly ordered and genetically determined process. It is relevant that the regulation of morphological differentiation and secondary metabolism are intimately connected. An intriguing example of this relationship is the finding described by Chater’s group1,2 that the reproductive phase and secondary metabolism does not begin in the absence of a particular leu-tRNA reading the rare UUA codon. Considering that antibiotics are the products of the secondary metabolism, the importance of the studies concerning these regulatory processes cannot be overestimated3. A promising field of research is the investigation of those endogenously produced substances (autoregulators) that were shown to influence the differentiation of Streptomyces (A-factor, B-factor, Pamamycin 607, and factor C, reviewed by Szabó et al.4).


Secondary Metabolism Neurospora Crassa Reproductive Phase Complex Life Cycle Streptomyces Strain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    E. J. Lawlor, H.A. Baylis and K. F. Chater, Pleiotropic morphological and antibiotic deficiencies result from mutations in a gene encoding a tRNA-like product in Streptomyces coelicolor A3(2), Genes Devt. 1: 1305–1310 (1987)CrossRefGoogle Scholar
  2. 2.
    K. F. Chater, E. J. Lawlor, C. Mendez, C. J. Bruton, N. K. Davis, K. Plaskitt, E. P. Guthrie, B. L. Daly, H.A. Baylis and K. Vu Trong, Gene expression during Streptomyces development, in: “Biology of Actinomycetes”, Y. Okami, T. Beppu and H. Ogawara eds., Japan Scientific Society Press, Tokyo, pp. 64–70 (1988).Google Scholar
  3. 3.
    D. A. Hopwood, Antibiotics: opportunities for genetic manipulation, Phil. Trans. R. Soc. Lond. B 324: 549–562 (1989).CrossRefGoogle Scholar
  4. 4.
    G. Szabó, F. Szeszâk, S. Vitâlis and F. Téth, New data on the formation and mode of action of factor C, in: “Biology of Actinomycetes”, Y. Okami, T. Beppu and H. Ogawara eds., Japan Scientific Society Press, Tokyo, pp. 324–329 (1988).Google Scholar
  5. 5.
    G. Szabó, T. Vâlyi-Nagy and S. Vitâlis, A new factor regulating life cycle of Streptomyces griseus. in: “Genetics of Microorganisms, Proc. Symp. on Heredity and Variability of Microorganisms”, V. D. Timakova, ed., State Publishing House of Medical Literature, Moscow, pp. 282–292 (1962).Google Scholar
  6. 6.
    S. Bíró, I. Békési, S. Vitâlis and G. Szabó, A substance effecting differentiation in Streptomyces griseus. Eur. J. Biochem. 103: 359–363 (1980).CrossRefGoogle Scholar
  7. 7.
    S. Vitâlis, and G. Szabó, Cytomrphological effect of factor C in submerged cultures on the hyphae of Streptomyces griseus strain No. 52–1, Acta Biol. Acad. Sci. Hung. 20: 85–92 (1969)PubMedGoogle Scholar
  8. 8.
    S. Vitâlis, G. Valu, I. Békési, F. Szeszâk and G. Szabó, Changes of protein pattern of Streptomyces griseus strains that characterize differentiation of mycelia in submerged culture, J. Basic Microbiol. 28: 393–407 (1988)CrossRefGoogle Scholar
  9. 9.
    F. Szeszâk, S. Vitâlis and G. Szabó, Factor C, a regulatory protein of Streptomyces griseus induces release of potassium from the mycelium, J. Basic Microbiol. 29: 233–240 (1989)Google Scholar
  10. 10.
    F. Szeszâk, S. Vitâlis, F. Téth, G. Valu, J. Fachet and G. Szabó, Detection and determination of factor C — a regulatory protein — in Streptomyces strains by antiserum and monoclonal antibody, Arch. Microbiol. in press, (1990).Google Scholar
  11. 11.
    J. G. Ensign, M. J. McBride, L. J. Stoxen, A. Bertinuson, M. Pomplun and A. Ho, The life cycle of Streptomyces: germination and properties of spores and regulation of sporulation, in: “Biological, Biochemical and Biomedical Aspects of Actinomycetes, G. Szabó, S. Mr() and M. Goodfellow, Akadémiai Kiadó, Budapest, pp. 777–790 (1986).Google Scholar
  12. 12.
    G. Szabó, S. Bíró, L. Trón, G. Valu, S. Vitâlis, Mode of action of factor C upon the differentiation process of Streptomyces griseus. in: “Biochemical and Biomedical Aspects of Actinomycetes”, L. Ortiz-Ortiz, L. F. Bojalil, V. Yakoleff, eds., Acad. Press, Orlando, pp. 197–214 (1984).Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • F. Szeszák
    • 1
  • S. Vitális
    • 1
  • I. Békési
    • 1
  • G. Szabó
    • 1
  1. 1.Institute of BiologyUniversity Medical SchoolDebrecenHungary

Personalised recommendations