Protein Biosynthesis and Secretion
Streptomyces are filamentous, Gram-positive microorganisms found generally in the soil and known mainly for their capacity to synthesize of numerous antibiotics and other secondary metabolites. They also produce a large number of extracellular enzymes which are essential to the degradation of biomass to assimilable carbon moieties. Generally these enzymes are hydrolases such as cellulases, xylanases, ligninases, amylases, lipases, nucleases etc. (Williams et al., 1983). Secretion is an essential and common feature to all these proteins.
KeywordsHeterologous Protein Streptomyces Griseus Xylanase Gene Tyrosinase Gene Disulfide Crosslinkages
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- Brawner, M., Taylor, D. and Fornwald, J., 1990, Expression of the soluble CD-4 receptor in Streptomyces. J. Cellular Biochem. Suppl. 14A: 103, UCLA symp. on molecular & cellular biology, Abstr. CCO36.Google Scholar
- Chang, S.-Y. and Chang, S., 1988, Secretion of heterologous proteins in Streptomyces lividans. Biology of Actinomycetes’88, Proc. 7 th Int. Symp. p. 103. Y. Okami, T. Beppu, H. Ogawara, eds.Google Scholar
- Jaurin, B., Granström, M. and Osterman, A., 1990, A recombinant system for extracellular production of polypeptides based on starch-inducible a-amylase promotor of Streptomyces. J. Cellular Biochem. Suppl. 14A: 126, UCLA Symp. on molecular & cellular biology, Abstr. CC408.Google Scholar