Molecular Genetic Investigation of Streptomyces Bambergiensis and Streptomyces Fradiae Strains, the Producers of Flavomycin and Tylosin
Streptomyces bambergiensis strains produce a phosphoglycolipid antibiotic complex flavomycin (moenomycin) [review Huber, 1978]. It is used in veterinary practice and is more active against Gram-positive bacteria. The antibiotics action mechanism is based on inhibition of the cell wall peptidoglycan synthesis. The antibiotics interact with enzymes catalyzing the transglycosylation reaction, in which a disaccharide unit is transferred from a phospholipid precursor to the growning peptidoglycan chain. The flavomycin complex antibiotics have relatively high molecular weight — about 2 kD — and a complicated structure: they contain oligosaccharide, phosphoglyceric acid, a C25-lipid alcohol moenocynol and a UV-chromophore. The genetics of S.bambergiensis and moenomycin biosynthesis is not studied well.
KeywordsStreptomyces Strain Multicopy Plasmid S712 Strain Phosphoglyceric Acid High Produce Strain
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