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Molecular Genetic Investigation of Streptomyces Bambergiensis and Streptomyces Fradiae Strains, the Producers of Flavomycin and Tylosin

  • A. V. Orekhov
  • S. B. Zotchev
  • G. Y. Florova
  • A. R. Foors
  • L. B. Gul’ko
  • S. M. Rosenfeld
  • V. G. Zhdanov
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 55)

Abstract

Streptomyces bambergiensis strains produce a phosphoglycolipid antibiotic complex flavomycin (moenomycin) [review Huber, 1978]. It is used in veterinary practice and is more active against Gram-positive bacteria. The antibiotics action mechanism is based on inhibition of the cell wall peptidoglycan synthesis. The antibiotics interact with enzymes catalyzing the transglycosylation reaction, in which a disaccharide unit is transferred from a phospholipid precursor to the growning peptidoglycan chain. The flavomycin complex antibiotics have relatively high molecular weight — about 2 kD — and a complicated structure: they contain oligosaccharide, phosphoglyceric acid, a C25-lipid alcohol moenocynol and a UV-chromophore. The genetics of S.bambergiensis and moenomycin biosynthesis is not studied well.

Keywords

Streptomyces Strain Multicopy Plasmid S712 Strain Phosphoglyceric Acid High Produce Strain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • A. V. Orekhov
    • 1
  • S. B. Zotchev
    • 1
  • G. Y. Florova
    • 1
  • A. R. Foors
    • 1
  • L. B. Gul’ko
    • 1
  • S. M. Rosenfeld
    • 1
  • V. G. Zhdanov
    • 1
  1. 1.Institute of Genetics and Selection of Industrial MicroorganismsMoscowUSSR

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