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Bromoperoxidase from Streptomyces Aureofaciens Tü24 and its Role in 7-Chlorotetracycline Biosynthesis

  • Helmut Häcker
  • Otto Pfeifer
  • Frauke Thiermann
  • Maria Weng
  • Franz Lingens
  • Karl-Heinz van Pée
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 55)

Abstract

Streptomyces aureofaciens Tü24 and S. aureofaciens ATCC 10762 both produce the antibiotics tetracycline and 7-chlorotetracycline. The biosynthetic pathway for tetracycline and 7-chlorotetracvcline is identical with the exception of the chlorination step (1, Fig. 1).

Keywords

Antibiotic Tetracycline Agar Diffusion Assay Streptomyces AUREOFACIENS Brominate Activity Gentamycin Resistance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    J.D.R.McCormick, Tetracyclines, in: “Antibiotics Vol II-Biosynthesis,” D. Gottlieb and P. D. Shaw, ed., Springer, Berlin-Heidelberg-New York (1967).Google Scholar
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    K.-H. van Pée, Molecular cloning and high-level expression of a bromoperoxidase gene from Streptomvces aureofaciens Tü24, J. Bacterial 170: 5890 (1988).Google Scholar
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    B. E. Krenn, H. Plat,and R. Weyer, Purification and some characteristics of a non-heure bromoperoxidase from Streptomyces aureofaciens, Biochim. Biophys. Acta 952:255 (1988).CrossRefGoogle Scholar
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Helmut Häcker
    • 1
  • Otto Pfeifer
    • 1
  • Frauke Thiermann
    • 1
  • Maria Weng
    • 1
  • Franz Lingens
    • 1
  • Karl-Heinz van Pée
    • 1
  1. 1.Institut für MikrobiologieUniversität HohenheimStuttgart 70Germany

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