The Pathogenesis of Epididymo-Testicular Dysfunction in Varicocele: Factors other than Temperature

  • Frank Comhaire
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 286)


Among factors accepted to cause impairment of sperm quality, clinical as well as subclinical varicoceles are the most common since they are detected in approximately one third of subfertile men. Several hypotheses have been proposed to explain the mechanism of epididymo-testicular dysfunction in these men. An important problem with the majority of these theories resides in the fact that they do not account for the observation that varicocele may have such a variable influence on testicular function, as to leaving it apparently unaltered in some cases and causing a total arrest of spermatogenesis and/or deficient androgen production in others.


Leydig Cell Spermatic Vein Venous Reflux Antisperm Antibody Internal Spermatic Vein 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Frank Comhaire
    • 1
  1. 1.Department of Internal MedicineState University HospitalGhentBelgium

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