Adhesion of Candida Albicans to Host Surfaces

  • L. J. Douglas
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 50)


Colonization of host surfaces by the pathogenic Candida species depends on the ability of the fungi to adhere. Adhesion enables the organisms to resist the flushing action of the fluids that continuously bathe such surfaces. In the case of mucosal surfaces, epithelial cells with adherent microorganisms are repeatedly lost by desquamation and so the progeny of these organisms much attach to newly exposed cells if colonization is to continue. This host defence mechanism provides a selective pressure which may result in the elimination of less adhesive organisms. Adhesion is, therefore, the first step in the process leading to persistent colonization and infection, and the ability to adhere constitutes an important virulence factor.


Adhesion Mechanism Buccal Cell Host Surface Extracellular Polymeric United Kingdom Introduction 
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  1. 1.
    L.J.Douglas, in: “The Yeasts”, Vol. 2, 2nd Edition, A. H. Rose and J.S. Harrison, eds., pp. 239–280, Academic Press, London (1987a)Google Scholar
  2. 2.
    L.J. Douglas, CRC Crit. Rev. Microhiol., 15: 27 (1987b).Google Scholar
  3. 3.
    L.H. Kimura and N.N. Pearsall, Tnfect-Tmmun., 21: 64 (1978).Google Scholar
  4. 4.
    R.D. King, J.C. Lee and A.L. Morris, Tnfect.Immun., 27: 667 (1980).Google Scholar
  5. 5.
    T.L. Ray, K.B. Digre and C.D. Payne, J.Invest. Dermatol., 83: 37 (1984).PubMedCrossRefGoogle Scholar
  6. 6.
    S.A. Klotz and R.L. Penn, Ciirr Microhiol, 16: 119 (1987).CrossRefGoogle Scholar
  7. 7.
    S.A. Klotz, D.J.Drutz, J.L. Harrison and M. Huppert, Infect. Immun., 42: 374 (1983).Google Scholar
  8. 8.
    P.A. Maisch and R.A. Calderone, Infect. immun., 27: 650 (1980).PubMedGoogle Scholar
  9. 9.
    L.J. Douglas and J.McCourtie, FEMS Microbiol.Lett., 16: 199 (1983)CrossRefGoogle Scholar
  10. 10.
    J.C. Lee and R.D. King, Infect. Immure., 41: 1024 (1983).Google Scholar
  11. 11.
    R.L. Sandin, A.L. Rogers, R.J. Patterson and E.S. Beneke, Infect. Immun., 35: 79 (1982).PubMedGoogle Scholar
  12. 12.
    E. Segal, N. Lehrer and I. Ofek, Ext. Cell Biol., 50: 13 (1982).Google Scholar
  13. 13.
    M.A. Ghannoum, G.R. Burns, K. Abu Elteen and S.S. Radwan, Infect. Immun., 54: 189 (1986).PubMedGoogle Scholar
  14. 14.
    I.A. Critchley and L.J. Douglas, J. Gen. Microhiol., 133: 637 (1987b).Google Scholar
  15. 15.
    J.D. Sobel, P.G. Myers, D. Kaye and M.E. Levison, J. Infect.. Dis., 143: 76 (1981).PubMedCrossRefGoogle Scholar
  16. 16.
    K.G. Skerl, R.A. Calderone, E. Segal, T. Sreevalsan and W.M. Scheld, Can. J. Microbiol., 30: 221 (1984).PubMedCrossRefGoogle Scholar
  17. 17.
    A.S.G. Curtis, in: “Adhesion of Microorganisms to Surfaces”, D.C. Ellwood, J. Melling and P. Rutter, pp. 199–208, Academic Press, London (1979).Google Scholar
  18. 18.
    J. McCourtie and L.J. Douglas, Infect. Immun., 45: 6 (1984).PubMedGoogle Scholar
  19. 19.
    J. McCourtie and L.J. Douglas, Infect. Immun., 32: 1234 (1981).PubMedGoogle Scholar
  20. 20.
    J. McCourtie and L.J. Douglas, J.Gen. Microbiol., 131: 495 (1985).PubMedGoogle Scholar
  21. 21.
    I.A. Critchley, Phil. D. Thesis, University of Glasgow (1986).Google Scholar
  22. 22.
    I.A. Critchley and L.J. Douglas, J. Gen. Microbiol., 133: 629 (1987a).PubMedGoogle Scholar
  23. 23.
    G.W. Jones and R.E. Isaacson, CRC Crit. Rev. Microbiol., 10: 229 (1983).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • L. J. Douglas
    • 1
  1. 1.Department of MicrobiologyUniversity of GlasgowGlasgowUK

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