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Proteinases Secreted by Candida Species

  • R. Rüchel
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 50)

Abstract

The extracellular proteolytic activity of C. albicans was discovered by Staib 1 and various secretory candidal proteinases have been characterized 2–9. The enzymes are aspartic proteinases (E.C.3.4.23.6) related to pepsin, renin, and cathepsin-D; like these, they are inhibited by pepstatin-A. Most Candida proteinases are glycoproteins of approximately 45 kD molecular mass; only a proteinase of C. parapsilosis had a mass of 33 kD 7. The nucleotide sequence of a proteinase gene of C. albicans has recently been published 10; howover, it is not clear at present, whether this gene codes for a secretory enzyme.

Keywords

Proteolytic Activity Aspartic Proteinase Candidal Cell Filamentous Cell Fungal Proteinase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • R. Rüchel
    • 1
  1. 1.Department of Medical MicrobiologyUniversity of GöttingenGöttingenThe Federal Republic of Germany

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