Transglucosylation Catalysed by the Exo-ß-Glucanase of Candida Albicans

  • P. A. Sullivan
  • G. W. Emerson
  • M. J. Broughton
  • H. J. Stubbs
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 50)


The β-1,3/1,6-glucan that constitutes 70% of the cell wall of Candida albicans 1 is qualitatively similar to the glucan of Saccharomyces cerevisiae but it contains higher proportions of branch points (7%) and β-1,6 linkages (43–50%)2.Cabib at al. 3 have reviewed the current understanding of the synthesis of the call wall. Linear chains of β-1,3 glucan are synthesized by a UDP-glucose synthetase located in the plasma membrane but nothing is known about the formation of β-1,6 oligosaccharide chains, branching or cross linking to other polymers. In this paper we describe a rapid transglucosylation reaction catalyzed by an exo-β-glucanase from C.albicans.


Candida Albicans Oligosaccharide Chain Glucosyl Unit Cell Wall Expansion Transferase Reaction 
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  1. 1.
    P.A.Sullivan, Y.Y.Chiew, C.Molloy, M.D.Templeton and M.G.Shepherd, Canad.J.Microbiol., 29: 1514 (1983).CrossRefGoogle Scholar
  2. 2.
    P.K.Gopal, M.G.Shepherd and P.A.Sullivan, J. Gen. Microbiol., 130: 3295 (1984).Google Scholar
  3. 3.
    E.Cabib, B.Bowers, A.Sburleti and S.J.Silverman, Microbiol. Sci. 5: 370 (1988).PubMedGoogle Scholar
  4. 4.
    S.P. Ram, L.K. Romana, M.G. Shepherd and P.A. Sullivan, J. Gen. Microbiol., 130: 1227 (1984).PubMedGoogle Scholar
  5. 5.
    S.P.Ram, K.H.Hynes, S.P.Romana, M.G.Shepherd and P.A.Sullivan, Life Science Advances - Biochemistry 7 (in press) (1988).Google Scholar
  6. 6.
    M.Molina, R.Cenamor and C.Nombela, J. Gen. Microbiol., 113: 609 (1987).Google Scholar
  7. 7.
    C.Nombela, M.Molina, R.Cenamor and M.Sanchez, Microbiol Sci., 5: 328 (1988).Google Scholar
  8. 8.
    A.G.Dickerson and R.C.F.Baker, J.Gen. Microbiol., 112: 67 (1979).Google Scholar
  9. 9.
    K.Nisizawa and Y.Hashimoto, in: “The Carbohydrates: Chemistry and Biochemistry”, W.W. Pigman and D. Horton, eds., pp. 241–300, Academic Press, New York (1970).Google Scholar
  10. 10.
    K.G.Nilsson, Tibtech., 6: 256 (1988).Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • P. A. Sullivan
    • 1
  • G. W. Emerson
    • 1
  • M. J. Broughton
    • 1
  • H. J. Stubbs
    • 1
  1. 1.Department of BiochemistryUniversity of OtagoDunedinNew Zealand

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