Pastorex Candida, a New Latex Agglutination Test for Mannan Detection in Serum of Patients with Invasive Candidosis

  • L. Meulemans
  • A. Andremont
  • F. Meunier
  • A. M. Ceuppens
  • M.-L. Garrigues
  • D. Stynen
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 50)


The increasing number of patients with virus and drug-induced immunodeficiencies has also lead to a higher incidence of invasive candidosis and other opportunistic infections. Because of the bad prognosis of systemic Candida infections, early and accurate diagnosis is very important. Diagnosis is difficult, however, since traditional methods as blood culture and antibody determination are not very reliable. This has stimulated research on the presence of Candida antigens circulating in the blood. Although several recent reports have focussed on a 47 kD cytoplasmic protein 1, 2, the most extensively studied circulating antigen is mannan, a major cell wall polysaccharide 3, 5. Its detection in patient serum is a good indicator for deep-seated disease 6, 7.


Invasive Aspergillosis Latex Agglutination Latex Bead False Positive Reaction Mannan Detection 
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  1. 1.
    R.C. Matthews and J.P. Burnie, J.Clin.Microbiol., 26: 459 (1988).PubMedGoogle Scholar
  2. 2.
    N.A. Strockbine, M.T. Largen, S.M. Zweibe, H.R. Buckley, Infect. Immun., 43: 715 (1984).PubMedGoogle Scholar
  3. 3.
    L. De Repentigny, R.J. Kuykendall, F.W. Chandler, J.R. Broderson and E. Reiss, J. Clin. Microbiol., 19: 804 (1984).PubMedGoogle Scholar
  4. 4.
    M.A. Lew, G.R. Siber, D.M. Donahue, F. Maiorca,, T.Tnfect.Dis., 45: 45 (1982).CrossRefGoogle Scholar
  5. 5.
    E. Reiss, L. Stockmann, R.J. Kuykendall, S.J. Smith, Clin.Chem., 28: 306 (1981).Google Scholar
  6. 6.
    F. Meunier-Carpentier and D. Armstrong, J.Clin.Microbiol., 13: 10 (1981).PubMedGoogle Scholar
  7. 7.
    M.H. Weiner and M. Coats-Stephen, J.Tnfect.Dis., 140: 929 (1979).Google Scholar
  8. 8.
    H. Bazin, in: “Methods of Hybridoma Formation”, A.H. Bartal and Y. Hirshout, eds., pp. 337–338, Humana Press, Clifton, N.J. (1987).CrossRefGoogle Scholar
  9. 9.
    A. Faure, D. Bladier, F. Fabia, P. Cornillot, in: “Protides of the Biological Fluids, Proc. 20th Colloquim”, H. Pecters, ed., Pergamon Press, Oxford (1973).Google Scholar
  10. 10.
    L. Kaufman and E. Reiss, in: “Manual of Clinical Laboratory Immunology”, 3rd Edition, N.R. Rose, H. Friedman, J.L. Fahey, eds., pp. 446–466, American Society for Microbiology, Washington D.C. (1986).Google Scholar
  11. 11.
    S. Fujita, F. Matsubara, T. Matsuda, J. Clin. Microbiol., 23: 568 (1986).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • L. Meulemans
    • 1
  • A. Andremont
    • 2
  • F. Meunier
    • 3
  • A. M. Ceuppens
    • 3
  • M.-L. Garrigues
    • 4
  • D. Stynen
    • 1
  1. 1.Eco-Bio NVGenkBelgium
  2. 2.Institut Gustave RoussyVillejuif CedexFrance
  3. 3.Institut BordetBrusselsBelgium
  4. 4.Diagnostics PasteurMarnes-la-CoquetteFrance

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