Pastorex Candida, a New Latex Agglutination Test for Mannan Detection in Serum of Patients with Invasive Candidosis
The increasing number of patients with virus and drug-induced immunodeficiencies has also lead to a higher incidence of invasive candidosis and other opportunistic infections. Because of the bad prognosis of systemic Candida infections, early and accurate diagnosis is very important. Diagnosis is difficult, however, since traditional methods as blood culture and antibody determination are not very reliable. This has stimulated research on the presence of Candida antigens circulating in the blood. Although several recent reports have focussed on a 47 kD cytoplasmic protein 1, 2, the most extensively studied circulating antigen is mannan, a major cell wall polysaccharide 3, 5. Its detection in patient serum is a good indicator for deep-seated disease 6, 7.
KeywordsInvasive Aspergillosis Latex Agglutination Latex Bead False Positive Reaction Mannan Detection
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