The Minor Salivary Gland Network in Experimental Oral Candidosis

  • M. Lacasse
  • C. Fortier
  • L. Trudel
  • A. J. Collet
  • N. Deslauriers
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 50)


Candida albicans-is an opportunistic pathogen capable of infecting many mucous membranes in humans including the oral mucosa. In order to achieve successful colonization, C. albicans must overcome both non-specific and specific defense mechanisms present in the saliva and at mucosal surfaces. Since the incidence of local infection and systemic dissemination is lower than expected from the ubiquity of the microorganism in the oral flora, immuno-surveillance mechanisms can therefore be expected to have a synergistic effect with oral bacterial competition in the normal handling of Candida1. Cell-mediated immunity may play a role in host resistance to mucosal candidal infections as suggested by Marra and Balish 2 and BudtzJörgensen 3 who correlated the clearing of the infection with the development of cellular hypersensitivity. In mucocutaneous candidosis, indirect evidence suggests that a major host defense mechanism against Candida could involve T lymphocytes 9. It is also possible to attribute a role to innate resistance in host defense against Candida. Some reports have demonstrated the in vitro effectiveness of peripheral NK cells against fungal pathogens 5–7, and polymorphonuclear cells are known to be of major importance in systemic candidosis (rev.4).


Mast Cell Soft Palate Candidal Infection Minor Salivary Gland Salivary Duct 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • M. Lacasse
    • 1
  • C. Fortier
    • 1
  • L. Trudel
    • 1
  • A. J. Collet
    • 2
  • N. Deslauriers
    • 1
  1. 1.GREB, Dental SchoolLaval UniversityQuebecCanada
  2. 2.Department of Anatomy, Faculty of MedicineLaval UniversityQuebecCanada

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