Virulence of Proteinase-Positive and Proteinase-Negative Candida Albicans to Mouse and Killing of the Yeast by Normal Human Leukocytes

  • S. Kuştimur
  • H. El-Nahi
  • N. Altan
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 50)


Candida infections, which are of opportunistic type are prevalently seen all over the world and C.albicans is the most frequently isolated species in human beings 1–4. Candida species may lead to a wide spectrum of diseases due to physiological changes that occur in healthy persons and to traumatic, hematologic,endocrinal and other predisposing factors 2,5,6. Species apart from C.albicans are responsible only for 10% of human candidiasis 7. There are several factors that have been suggested as contributing to the pathogenicity of C.albicans8–18. Among them the secretory acid proteinase enzyme has been accepted lately by many investigators to play an important role in the pathogenicity of this microorganism 12–21. This enzyme is produced primarily by C.albicans. However, some less pathogenic species like C.tropicalis and C.parapsilosis also manufacture the enzyme 13–15.


Candida Albicans Candida Species Candida Infection Acid Proteinase Candida Strain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • S. Kuştimur
    • 1
  • H. El-Nahi
    • 1
  • N. Altan
    • 2
  1. 1.Department of Microbiology Faculty of MedicineGazi UniversityAnkaraTurkey
  2. 2.Department of Biochemistry Faculty of MedicineGazi UniversityAnkaraTurkey

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