Adhesion of Candida to Murine Gastrointestinal Mucosa of Animals Treated with Anti-Cancer Therapy and Inhibition by a Chitin Derivative
It is well established that Candida albicans is an inhabitant of the gastrointestinal (GI) tract in a significant proportion of the normal population 20–65%1. In debilitated individuals, following various treatments such as broad spectrum antibiotics, irradiation or anti-cancer cytotoxic drugs, an increased colonization of the GI system is observed (56–75%)2.
KeywordsCandida Albicans Spleen Weight Tissue Disk Untreated Control Mouse Chitin Derivative
Unable to display preview. Download preview PDF.
- 2.G. P. Body, Candidiasis in cancer patients, Am. J. Med., 77 (4D): 13 (1984).Google Scholar
- 5.C. Hawkins and D. Armstrong, Fungal infections in the immunocompromised host, Clin. Hematol., 13: 599 (1984).Google Scholar
- 6.A. Ofek, and E.G. Beachey, General concepts and principles of bacterial adherence in animals and man, in: “Bacterial Adherence (Receptors and Recognition)”, Series B:6, E.G.Reachey, ed., pp. 3–29, Chapman and Hall, London (1980).Google Scholar
- 7.E. Segal, Pathogenesis of human mycoses: role of adhesion to host surfaces, Microbiol. Sci., 4: 344 (1987).Google Scholar
- 8.M. Kahane, E. Segal, M. Schewach-Millet and Y. Gov, In vitro adherence of Candida albicans to corneocytes, inhibition by chitin soluble extract, Acta Dermatol. Venerol., 68:98 (1988).Google Scholar
- 9.N. Lehrer, E. Segal and L. Barr-Nea, In vitro and in vivo adherence of Candida albicans to mucosal surfaces. Ann. Microbiol., 134B:293 (1983).Google Scholar