Candida Albicans — Platelet Interaction: Evidence for, in Vivo and in Vitro, Cell to Cell Attachment

  • C. Mahaza
  • R. Robert
  • M. Miègeville
  • G. Tronchin
  • J. M. Senet
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 50)


It is possible to elucidate the physiopathology of candidosis by evaluating the different parameters involved in the relationship between C. albicans and its hosts. The different steps of the host colonization which can be evaluated are: adherence, multiplication and dissemination through the organism. When this dissemination is via the blood stream, the yeasts interact with blood components such as fibrinogens1, fibronectin2, complements3, leukocytes and platelets. In vivo experiments show the attachment of C. albicans to platelet aggregates. In vitro, electron microscopic observations demonstrate that the platelets adhere, protrude spikes and finally spread and flattened on the upper fibrillar layer of the fungus.


Candida Albicans Germ Tube Human Platelet Platelet Aggregate Uranyle Acetate 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • C. Mahaza
    • 1
  • R. Robert
    • 1
  • M. Miègeville
    • 2
  • G. Tronchin
    • 1
  • J. M. Senet
    • 1
  1. 1.Laboratoire de’Immunologie-Parasitologie-MycologieUFR des Sciences Médicales et Pharmaceutiques, Section PharmacieAngersFrance
  2. 2.Laboratoire de ParasitologieFaculté de PharmacieNantesFrance

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