Effect of Blood Group and Secretor Status on the Adhesion of Candida Albicans to Mucosal Surfaces
Adhesion of Candida albicans to epithelial cells is the first stage in the colonization of mucosal surfaces by this organism. Although the mechanism of adhesion is not fully established, there is now considerable evidence for the involvement of glycosides as epithelial receptors for the yeast 1,2. A number of studies have demonstrated that, in vitro, C. albicans adheres more readily to exfoliated buccal or vaginal epithelial cells from some donors than from others 3,4, suggesting that some individuals may be more susceptible to colonization by the yeast. Recently, Burford-Mason et al. 5 reported that oral carriage of C. albicans in healthy subjects could be correlated with two host factors, namely blood group 0 and non-secretion of blood-group antigens, with the trend towards carriage being greatest in group 0 non-sectors. In the present study we have investigated the effect of donor blood group and secretor status on adhesion of C. albicans to buccal epithelial cells in vitro.
KeywordsSugar Glycoside Candida Fucose
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