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Ultrastructure and Growth of Candida Albicans Associated with Rat Vaginal Epithelium

  • P. A. Hunter
  • A. Everett
  • J. Warrack
  • M. Wilkinson
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 50)

Abstract

The rodent model of Candida vaginitis is widely used to examine the effects of antifungal agents, and several studies of the pathogenesis of the infection, particularly in rats, have been made1–3. Differences exist between the infection in rodents and humans, particularly the presence of an extensive squamous keratinised vaginal epithelium, higher vaginal pH and lack of an inflammatory response in rodents, and differences in the vaginal flora. However, a true vaginitis is produced in the rat and the model offers considerable advantages for testing drugs, since the infection is benign, causing little discomfort to the animal, is reasonably reproducible and persists for several months.

Keywords

Stratum Corneum Viable Count Hyphal Growth Vaginal Swab Vaginal Epithelium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    A. Polak, Experimental Candida vaginitis (Vaginal Thrush), in: “Experimental Models in Antimicrobial Chemotherapy”, Vol. 2, Zak and Sande, eds. (1986).Google Scholar
  2. 2.
    H.J. Scholer, Experimentalle Vaginal-Candidiasis der Ratte, Pathologia et Microbiologia, 23: 62 (1960).PubMedGoogle Scholar
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    J.D. Sobel, G. Muller and J.F. McCormick, Experimental chronic vaginal candidosis in rats, Sabouraudia, 23: 199 (1985).PubMedCrossRefGoogle Scholar
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    R.J. McRipley, P.J. Erhard, R.A. Schwind and R.R. Whitney, Evaluation of vaginal antifungal formulations in vivo, Postgrad.Med.J., 55: 648 (1979).PubMedCrossRefGoogle Scholar
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    J.F. Reyley and S. McGregor, Quantification of vaginal Candida albicans infections in rodents, J.Med.Vet.Mycol., 24: 455 (1986).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • P. A. Hunter
    • 1
  • A. Everett
    • 1
  • J. Warrack
    • 2
  • M. Wilkinson
    • 2
  1. 1.Biosciences Research CentreEpsom, SurveyUK
  2. 2.Chemotherapeutic Research CentreBetchworth, SurveyUK

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