Experimental Candidosis in Animals and Chemotherapy

  • J. Van Cutsem
  • F. Van Gerven
  • J. Fransen
  • P. A. J. Janssen
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 50)


Members of the genus Candida are widely spread. They are present as endosaprophytes in the gastrointestinal tract of man and the majority of animals or as exosaprophytes in the environment. Various Candida spp. may be responsible for pathological manifestations, but Candida albicans is considered to be the species with the highest potency for morbidity and mortality, mainly in immunocompromised individuals or when predisposing, known or unknown, factors or regimens are present. Any organ may be infected, but superficial infections constitute by far the highest incidence.


Colony Form Unit Parenteral Treatment Medical Mycology Prednisolone Acetate Small Eruption 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    G.Maestrone and R.Semar, Establishment and treatment of cutaneous Candida albicans infection in the rabbit, Naturwissenschaften, 55: 87 (1968).PubMedCrossRefGoogle Scholar
  2. 2.
    F.C.Odds, “Candida and Candidosis”, 2nd ed.,pp. 282–283, Baillière Tindall, W.B. Saunders, London (1988).Google Scholar
  3. 3.
    A.Polak, Experimental Candida vaginitis (vaginal thrush), in: “Experimental Models in Antimicrobial Chemotherapy”, Vol.2, D.Zak and M.A.Sande, eds., pp. 21–42, Academic Press, London (1986).Google Scholar
  4. 4.
    T.L.Ray, Animal models of experimental Candida infections of the skin, in: “Models in Dermatology”, Vol.1, H.I.Maibach and N.J. Lowe, eds., pp. 41–50, Karger, Basel (1985).Google Scholar
  5. 5.
    M.G.Rinaldi, In-vivo models of the mycoses for the evaluation of antifungal agents, in: “Recent Trends in the Discovery, Development and Evaluation of Antifungal Agents”, R.A.Fromtling, ed., pp.S1: 11–24, Prous J.R.Science Publ., Barcelona (1987).Google Scholar
  6. 6.
    H.J.Scholer, 1960, Experimental Vaginal-Candidiasis der Ratte, Pathol.Microbiol., 23: 62 (1960).Google Scholar
  7. 7.
    D.Thienpont, J.Van Cutsem, M.Borgers, Ketoconazole in experimental candidosis, Rev Inf.Dis., 2: 570 (1980).CrossRefGoogle Scholar
  8. 8.
    J.Van Cutsem, D.Thienpont, Experimental cutaneous Candida albicans infections is guinea-pigs, Sahouraudia, 9: 17 (1971).CrossRefGoogle Scholar
  9. 9.
    J.Van Cutsem, The antifungal activity of ketoconazole, Am.J.Med., 74: 1B, 9 (1983).Google Scholar
  10. 10.
    J.Van Cutsem, F.Van Gerven, P.A.J. Janssen, Activité anticandidose des azoles, Ann.Biol.Clin., 45: 661 (1987).Google Scholar
  11. 11.
    J.Van Cutsem, J.Fransen, P.A.J.Janssen, Therapeutic efficacy of itraconazole in systemic candidosis in guinea-pigs, Chemotherapy, 33: 52 (1987).PubMedCrossRefGoogle Scholar
  12. 12.
    J.Van Cutsem, F.Van Gerven, P.A.J.Janssen, Activity of orally, topically and parenterally administered itraconazole in the treatment of superficial and deep mycoses. Animal models, Rev.Infect.Dis., 9: SI, 15 (1987).Google Scholar
  13. 13.
    J.Van Cutsem, F.Van Gerven, P.A.J. Janssen, Oral therapeutic treatment of vaginal candidosis in rats with itraconazole, fluconazole and ketoconazole: comparison of one-, two-and three-day treatment schedules, in: “Proceedings of the 15th International Congress of Chemotherapy: Progress in Antimicrobial and Anticancer Chemotherapy, Istanbul, Turkey, 19–24 June 1987”, B. Berkarda and H.P.Kuemmerle, eds., Vol.1, pp. 879–881 (1987).Google Scholar
  14. 14.
    J.Van Cutsem, Animal models for dermatomycotic infections, in: “Current Topics in Medical Mycology”, Vol. 3, M.R.McGinnis and M.Borgers, eds., Springer-Verlag, Publ., New York, 1989 (in press).Google Scholar
  15. 15.
    Van Cutsem, J., 1989, In-vitro sensitivity of Candida spp. to antifungals. Treatment of experimental candidosis with itraconazole, in: “Proceedings of FEMS-Symposium on Candida and Candida-mycosis, Alanya, Turkey, 24–28 April 1989”, Plenum, London (1990).Google Scholar
  16. 16.
    A.Wildfeuer, Die Chemotherapie der vaginalen Trichomoniasis and Candidosis der Maus, Arzneimittelforschung (Drug Res.), 24: 937 (1974).Google Scholar
  17. 17.
    H.Yamaguchi, Opportunistic fungal infections, Candidiasis, in: “Animal Models in Medical Mycology”, M.Miyaji, ed., pp. 111–112 and 144–151, C.R.C.Press, Inc., Boca Raton (1987).Google Scholar
  18. 18.
    P.M.Laduron and P.F.M.Janssen, 1986, Impaired axonal transport of opiate and muscarinic receptors in streptozotocin-diabetic rats, Brain Res., 380: 359 (1986).Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • J. Van Cutsem
    • 1
  • F. Van Gerven
    • 1
  • J. Fransen
    • 1
  • P. A. J. Janssen
    • 1
  1. 1.Janssen Research FoundationBeerseBelgium

Personalised recommendations