Primary Structure and Functional Expression of the Inositol 1,4,5-Trisphosphate Receptor, P400
There are several signal transduction pathways inside the cell/ such as the C-kinase/ A-kinase/ and calmodulin dependent protein kinase Systems. These Systems exert physioI09icat func-tions through phosphoryIation. However/ it is well known that calcium ions play an important role in physi0IogicaI functions/ and recently/ it has been demonstrated that inositol trisphos-phate/ a counterpart of diacy I g I ycer01 (DG) hydrolysed from phosphatidyl inositol di-Phosphates/ mobil izes calcium ions from calcium storage sites inside the cell (Berridge* 1987). Although many researchers have been working on calcium mobili-zation/ no detailed mechanism was known. Many questions have arisen/ for example/ do putative lnsP3 receptors have both lnsP3 binding sites and calcium Channels or not/ is the calcium Channel a different molecule from the lnsP3 receptor or not.
KeywordsPurkinje Cell P400 Protein Ryanodine Receptor Inositol Trisphosphate Mouse Cerebellum
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