NMDA Receptor Agonists: Relationships between Structure and Biological Activity
The acidic amino acids L-aspartic acid (ASP) and, in particular, L-glutamic acid (GLU) are generally accepted to be the major excitatory amino acid (EAA) neurotransmitters in the mammalian central nervous system (CNS). Hyperactivity of central EAA neuronal pathways has been associated with the etiology of certain neurodegenerative diseases, such as status epilepticus, Huntington’s chorea and dementia of the Alzheimer type (Lodge, 1988; Rothman and Olney, 1986; Greenamyre 1986; Greenamyre et al., 1988; Bridges et al., 1988). In Alzheimer patients a regional degeneration of cholinergic, noradrenergic and serotonergic neurones is observed (Narang and Cutler, 1986).
KeywordsStatus Epilepticus Excitatory Amino Acid Kainic Acid Ibotenic Acid Excitatory Amino Acid Receptor
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