Novel Fourth Binding Sites of [3H]Spermidine within the NMDA Receptor Complex

  • Yukio Yoneda
  • Kiyokazu Ogita
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 287)


N-Methyl-D-aspartic acid (NMDA)-sensitive subclass of the synaptic receptors for central excitatory amino acid neurotransmitters is supposed to form a receptor ion channel complex with modulatory glycine (Gly) binding sites which are insensitive to a classical Gly antagonist strychnine (for example, see review by Robinson and Coyle, 1987), based on the electrophysiological findings that Gly drastically potentiates in a strychnine-insensitive manner currents mediated by the NMDA-sensitive subclass without affecting those mediated by the other subclasses in cultured neuronal cells (Johnson and Ascher, 1987). The complex consists of at least three distinctly different sites; 1) NMDA recognition sites, 2) ion channel sites and 3) Gly recognition sites. The latter strychnine-insensitive Gly sites are referred to as GlyB sites to differentiate them from the strychnine-sensitive GlyA sites just for convenience’ sake (Ogita et al., 1989).


Synaptic Membrane Excitatory Amino Acid Receptor NMDA Channel NMDA Receptor Complex Untreated Membrane 


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Yukio Yoneda
    • 1
  • Kiyokazu Ogita
    • 1
  1. 1.Department of Pharmacology, Faculty of Pharmaceutical SciencesSetsunan UniversityHirakata, Osaka 573-01Japan

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