Novel Fourth Binding Sites of [3H]Spermidine within the NMDA Receptor Complex

  • Yukio Yoneda
  • Kiyokazu Ogita
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 287)


N-Methyl-D-aspartic acid (NMDA)-sensitive subclass of the synaptic receptors for central excitatory amino acid neurotransmitters is supposed to form a receptor ion channel complex with modulatory glycine (Gly) binding sites which are insensitive to a classical Gly antagonist strychnine (for example, see review by Robinson and Coyle, 1987), based on the electrophysiological findings that Gly drastically potentiates in a strychnine-insensitive manner currents mediated by the NMDA-sensitive subclass without affecting those mediated by the other subclasses in cultured neuronal cells (Johnson and Ascher, 1987). The complex consists of at least three distinctly different sites; 1) NMDA recognition sites, 2) ion channel sites and 3) Gly recognition sites. The latter strychnine-insensitive Gly sites are referred to as GlyB sites to differentiate them from the strychnine-sensitive GlyA sites just for convenience’ sake (Ogita et al., 1989).


Synaptic Membrane Excitatory Amino Acid Receptor NMDA Channel NMDA Receptor Complex Untreated Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Yukio Yoneda
    • 1
  • Kiyokazu Ogita
    • 1
  1. 1.Department of Pharmacology, Faculty of Pharmaceutical SciencesSetsunan UniversityHirakata, Osaka 573-01Japan

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