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Functions of a Co-Transmitter, Calcitonin Gene-Related Peptide, on the Neuromuscular Junction

  • Shuji Uchida
  • Kenji Takami
  • Hideyuki Kobayashi
  • Kazuya Hashimoto
  • Naoko Matsumoto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 287)

Abstract

Calcitonin gene-related peptide (CGRP) is a peptide that is synthesized in nervous tissues by a different processing of the messenger RNA for calcitonin (Amara et al.,1982; Rosenfeld et al.,1983) . A wide, but non-random distribution of CGRP-like immunoreactive structures in the central and peripheral nervous system has been demonstrated by immunohistochemistry and radioimmunoassay (Rosenfeld et al.,1983; Gibson et al.,1984; Kawai et al.,1985). CGRP has been shown to cause physiological responses and to have specific binding sites, suggesting that it is a neurotransmitter or neuromodulator.

Keywords

Adenylate Cyclase Phrenic Nerve Skeletal Muscle Cell Adenylate Cyclase Activity CGRP Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Shuji Uchida
    • 1
  • Kenji Takami
    • 1
  • Hideyuki Kobayashi
    • 1
  • Kazuya Hashimoto
    • 1
  • Naoko Matsumoto
    • 1
  1. 1.Department of Pharmacology 1, School of MedicineOsaka UniversityKitaku, Osaka 530Japan

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