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Excitatory Amino Acid Receptors in the Xenopus Oocyte Expression System

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Book cover Neuroreceptor Mechanisms in Brain

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 287))

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Abstract

The excitatory amino acid (EAA) receptors are neurotransmitter receptors responsive to glutamate, aspartate, and perhaps also to homocysteate or related compounds (Fonnum, 1984; Do et al., 1986). Although the nomenclature is still somewhat unsettled, electrophysiologists have identified at least two EAA receptors, namely the well-known N-methyl-D-aspartate (NMDA) receptor and a less well characterized “non-NMDA” receptor that can be powerfully activated by kainic acid and (RS)-α-amino-3-hydroxy-5-methyl-isoxazole-4-propionate (AMPA). A third receptor, stimulated by glutamate, quisqualate and ibotenate, is linked via a G-protein to the activation of phospholipase C and consequent generation of the second messenger, inositol tnsphosphate (Sugiyama et al., 1987). Due to their speed of activation (within millisec of applying agonist, e.g., Benveniste et al., 1990), the NMDA and non-NMDA receptors are thought to be receptor-channel complexes similar in architecture to the nicotinic acetylcholine receptor; i.e., all ligand binding sites and ion permeation pathways are thought to reside within the same macromolecular complex. The discussion that follows focuses on these two receptor-channel complexes.

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Authors and Affiliations

  1. Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA

    Raymond Dingledine, Nancy W. Kleckner & Christopher J. McBain

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  1. Raymond Dingledine
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  2. Nancy W. Kleckner
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Editors and Affiliations

  1. Division of Health Sciences, University of the Air, 2-11 Wakaba, Chiba 260, Japan

    Shozo Kito

  2. Department of Pharmacology Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku Hiroshima 734, Japan

    Tomio Segawa

  3. Department of Pharmacology Center for Health Sciences, University of California-Los Angeles School of Medicine, Los Angeles, California, 90024, USA

    Richard W. Olsen

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© 1991 Plenum Press, New York

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Dingledine, R., Kleckner, N.W., McBain, C.J. (1991). Excitatory Amino Acid Receptors in the Xenopus Oocyte Expression System. In: Kito, S., Segawa, T., Olsen, R.W. (eds) Neuroreceptor Mechanisms in Brain. Advances in Experimental Medicine and Biology, vol 287. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5907-4_39

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  • DOI: https://doi.org/10.1007/978-1-4684-5907-4_39

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