Heterogeneous Distribution of Glutamate Receptor Subtypes in Hippocampus as Revealed by Calcium Fluorometry
Recent advances in the fluorometry of intracellular Ca2+ concentration ([Ca2+]i) enabled detecting the time course and the two-demensional distribution of [Ca2+ ]i in single isolated cells as well as the tissue preparations (Kudo and Ogura, 1986; Nohmi et al., 1989). Since the role of Ca2+ on the modulation of the efficacy of synaptic transmission (synaptic plasticity) has been suggested from physiological and biochemical studies, the methods have been applied to neuronal cells in culture and brain slices, and elevations of [Ca2+]i during neuronal activity have directly been shown (Connor et al., 1988; Kudo et al., 1987).
KeywordsNMDA Receptor Glutamate Receptor Hippocampal Neuron Dentate Gyrus Mossy Fiber
Unable to display preview. Download preview PDF.
- Murphy, S.N. and Miller, R.J. 1989, Regulation of Ca2+influx into striatal neurons by kainic acid. J. Pharmacol. Exp. Therap., 249: 184–193 .Google Scholar
- Ogura, A., Akita, K. and Kudo, Y. 1989, Cytosolic calcium rise mediated by non-NMDA receptors in cultured rat hippocamapl neurons. Soc. Neurosci. Abs. 15: p1161 .Google Scholar