Heterogeneous Distribution of Glutamate Receptor Subtypes in Hippocampus as Revealed by Calcium Fluorometry

  • Yoshihisa Kudo
  • Etsuro Ito
  • Akihiko Ogura
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 287)


Recent advances in the fluorometry of intracellular Ca2+ concentration ([Ca2+]i) enabled detecting the time course and the two-demensional distribution of [Ca2+ ]i in single isolated cells as well as the tissue preparations (Kudo and Ogura, 1986; Nohmi et al., 1989). Since the role of Ca2+ on the modulation of the efficacy of synaptic transmission (synaptic plasticity) has been suggested from physiological and biochemical studies, the methods have been applied to neuronal cells in culture and brain slices, and elevations of [Ca2+]i during neuronal activity have directly been shown (Connor et al., 1988; Kudo et al., 1987).


NMDA Receptor Glutamate Receptor Hippocampal Neuron Dentate Gyrus Mossy Fiber 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Yoshihisa Kudo
    • 1
  • Etsuro Ito
    • 2
  • Akihiko Ogura
    • 1
  1. 1.Department of NeuroscienceMitsubishi Kasei Institute of Life SciencesMinamiooya, Machida, Tokyo 194Japan
  2. 2.Advanced Research Center for Human SciencesWaseda UniversityTokorozawa, Saitama 359Japan

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