Expression of the GABAB Receptor in Xenopus Oocytes and Desensitization by Activation of Protein Kinase C

  • Kohtaro Taniyama
  • Koichiro Takeda
  • Hiroshi Ando
  • Chikako Tanaka
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 287)


The γ-aminobutyric acid (GABA) receptors have been classified into two subtypes, termed GABAA and GABAB receptors, in the basis of their pharmacological properties (Bowery et al., 1984; 1989; Bormann, 1988). The GABAA receptor with its integrated Cl-channel is now well characterized. Studies revealed the amino acid sequence of the GABAA receptor (Schofield et al., 1987; Levitan et al., 1988). Stimulation of the GABAB receptor has been shown to induce two membrane effects, namely reduction in Ca2+ conductance and increase in K+ conductance (Bormann, 1988; Bowery, 1989), however, the GABAB receptor has not been purified. The expression of GABAB receptor in the Xenopus oocytes may provide information on molecular mechanisms of GABAB receptor-mediated responses.


GABAA Receptor Xenopus Oocyte Phorbol Ester Pertussis Toxin GABAB Receptor 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Kohtaro Taniyama
    • 1
  • Koichiro Takeda
    • 1
  • Hiroshi Ando
    • 1
  • Chikako Tanaka
    • 1
  1. 1.Department of PharmacologyKobe University School of MedicineKobe 650Japan

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