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Expression of the GABAB Receptor in Xenopus Oocytes and Desensitization by Activation of Protein Kinase C

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Neuroreceptor Mechanisms in Brain

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 287))

Abstract

The γ-aminobutyric acid (GABA) receptors have been classified into two subtypes, termed GABAA and GABAB receptors, in the basis of their pharmacological properties (Bowery et al., 1984; 1989; Bormann, 1988). The GABAA receptor with its integrated Cl-channel is now well characterized. Studies revealed the amino acid sequence of the GABAA receptor (Schofield et al., 1987; Levitan et al., 1988). Stimulation of the GABAB receptor has been shown to induce two membrane effects, namely reduction in Ca2+ conductance and increase in K+ conductance (Bormann, 1988; Bowery, 1989), however, the GABAB receptor has not been purified. The expression of GABAB receptor in the Xenopus oocytes may provide information on molecular mechanisms of GABAB receptor-mediated responses.

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Authors and Affiliations

  1. Department of Pharmacology, Kobe University School of Medicine, Kobe 650, Japan

    Kohtaro Taniyama, Koichiro Takeda, Hiroshi Ando & Chikako Tanaka

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  1. Kohtaro Taniyama
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  2. Koichiro Takeda
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  3. Hiroshi Ando
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  4. Chikako Tanaka
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Editors and Affiliations

  1. Division of Health Sciences, University of the Air, 2-11 Wakaba, Chiba 260, Japan

    Shozo Kito

  2. Department of Pharmacology Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku Hiroshima 734, Japan

    Tomio Segawa

  3. Department of Pharmacology Center for Health Sciences, University of California-Los Angeles School of Medicine, Los Angeles, California, 90024, USA

    Richard W. Olsen

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© 1991 Plenum Press, New York

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Taniyama, K., Takeda, K., Ando, H., Tanaka, C. (1991). Expression of the GABAB Receptor in Xenopus Oocytes and Desensitization by Activation of Protein Kinase C. In: Kito, S., Segawa, T., Olsen, R.W. (eds) Neuroreceptor Mechanisms in Brain. Advances in Experimental Medicine and Biology, vol 287. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5907-4_36

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  • DOI: https://doi.org/10.1007/978-1-4684-5907-4_36

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5909-8

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