Evidence for Cardiovascular Roles of Tachykinin Peptides in the Brain of the Rat

  • Hiro-o Kamiya
  • Yukio Takano
  • Akira Nagashima
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 287)


In addition to substance P (SP), 4 other tachykinin peptides have so far been isolated from the mammalian nervous system, namely neurokinin A (NKA), neuropeptide K (NPK), neuropeptide γ (NPγ) and neurokinin B (NKB) (Maggio, 1988; Krause et al., 1989). These tachykinin peptides have a variety of pharmacological effects, indicating smooth muscle contraction, salivation, endothelium-dependent vasodilator actions, and depolarization of central neurons (Erspamer, 1981; Pernow, 1983). These peptides are extensively distributed and play important physiological roles in the mammalian central nervous system (CNS). Several lines of evidence have proposed the existence of multiple tachykinin receptor subtypes in peripheral tissues and the CNS, called NK-1, NK-2 and NK-3 (TABLE I). SP, NKA and NKB are considered to be endogenous ligands of the NK-1, NK-2 and NK-3 subtypes, respectively (Henry, 1987).


Ventral Tegmental Area Nucleus Tractus Solitarius Supraoptic Nucleus Nodose Ganglion Nucleus Ambiguus 
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  1. Bergstrom, L., Torrens, Y., Saffroy, M.., Beaujouan, J.C., Lavielle, S., Chassaing, G., Morgat, J.L., Glowinski, J. and Marquet, A., 1987, [3H]neurokinin B and 125I-Bolton Hunter eledoisin label identical tachykinin binding sites in the rat brain, J. Neurochem., 48: 125–133.PubMedCrossRefGoogle Scholar
  2. Crill, N.E. and Reis, D.J., 1968, Distribution of carotid sinus and depressor nerves in the cat brainstem, Am. J. Physiol., 214: 269–276.PubMedGoogle Scholar
  3. Erspamer, V., 1981, The tachykinin peptide family, Trends Neurosci., 4: 267–269.CrossRefGoogle Scholar
  4. Helke, C.J., O’Donohue, T.L. and Jacobowitz, D.M, 1980, Substance P as a baro-and chemoreceptor afferent neurotransmitter: immunocyto-chemical and neurochemical evidence in the rat, Peptide, 1:1–9.CrossRefGoogle Scholar
  5. Henry, J.L., 1987, “Substance P and Neurokinins”, Springer, New York.CrossRefGoogle Scholar
  6. Higuchi, Y., Takano, Y., Shimazaki, H., Shimohigashi, Y., Kodama, H., Matsumoto, H., Sakaguchi, K., Nonaka, S., Saito, R., Waki, M. and Kamiya, H., 1989, Dimeric substance P analogue shows a high potent activity of the in vivo salivary secretion in the rat, Eur. J. Pharmacol., 160: 413–416.PubMedCrossRefGoogle Scholar
  7. Krause, J.E., MacDonald, M.R. and Takeda, Y., 1989, The polyprotein nature of substance P precursors, BioEssays, 10: 62–69.PubMedCrossRefGoogle Scholar
  8. Lipski, J., MacAllen, R.M. and Spyer, K.M., 1975, The sinus nerve and baroreceptor input to the medulla of cat, J.Physiol. (Lond.), 251: 61–78.Google Scholar
  9. Loewy, A.D. and Sawyer, W.B., 1982, Substance P antagonist inhibits vasomotor responses elicited from ventral medulla in rat, Brain Res., 245: 379–383.PubMedCrossRefGoogle Scholar
  10. Maggio, J.E., 1988, Tachykinins, Annu. Rev. Neurosci., 11: 13–28.PubMedCrossRefGoogle Scholar
  11. Nagashima, A., Takano, Y., Masui, H. and Kamiya, H., 1987, Evidence that neurokinin A (substance K) neurons project from the striatum to the substntia nigra in the rats, Neurosci. Lett., 77: 103–108.PubMedCrossRefGoogle Scholar
  12. Nagashima, A., Takano, Y., Tateishi, K., Matsuoka, Y., Hamaoka, T. and Kamiya, H., 1989a, Cardiovascular roles of tachykinin peptides in the nucleus tractus solitarii of rats, Brain Res., 487: 392–396.PubMedCrossRefGoogle Scholar
  13. Nagashima, A., Takano, Y., Tateishi, K., Matsuoka, Y., Hamaoka, T. and Kamiya, H., 1989b, Central pressor actions of neurokinin B: increases in neurokinin B contents in discrete nuclei in spontaneously hypertensive rats, Brain Res., 499: 198–203.PubMedCrossRefGoogle Scholar
  14. Panenton, W.M. and Loewy, A.D., 1980, Projections of the cartid sinus nerve to the nucleus of the solitary tract in the cat, Brain Res., 191: 239–244.CrossRefGoogle Scholar
  15. Pernow, B., 1983, Substance P, Pharmacol. Rev., 5: 85–141.Google Scholar
  16. Saffroy, M., Beaujouan, J.C., Torrens, Y., Besseyre, J., Bergstrom, L. and Glowinski, J., 1988, Localization of tachykinin binding sites (NK1, NK2, NK3 ligands) in the rat brain, Peptides, 9: 227–241.PubMedCrossRefGoogle Scholar
  17. Takano, Y., Martin, J.E., Leeman, S.E. and Loewy, A.D., 1984, Substance P immunoreactivity released from rat spinal cord after kainic acid excitation of the ventral medulla oblongata: a correlation with increased blood pressure, Brain Res., 291:168–172.PubMedCrossRefGoogle Scholar
  18. Takano, Y., Sawyer,W.B. and Loewy, A.D., 1985, Substance P mechanisms of the spinal cord related to vasomotor tone in the spontaneously hypertensive rat, Brain Res., 334: 106–116.CrossRefGoogle Scholar
  19. Takano, Y., Nagashima, A., Masui, H., Kuromizu, K. and Kamiya, H., 1986, Distribution of substance K (neurokinin A) in the brain and peripheral tissues of rats, Brain Res., 369: 400–404.PubMedCrossRefGoogle Scholar
  20. Takano, Y., Nagashima, A., Kamiya, H., Kurosawa, M. and Sato, A., 1988, Well-maintained reflex responses of sympathetic nerve activity tostimulation of baroreceptor, chemoreceptor and cutaneous mechanoreceptors in neonatal capsaicin treated rats, Brain Res., 455:188–192.Google Scholar
  21. Tateishi, K., Matsuoka, Y. and Hamaoka, T., 1989, Establishment of highly specific radioimmunoassay for neurokinin A and neurokinin B and determination of tissue distribution of these peptides in the rat central nervous system, Regul. Pept., 24: 245–257.PubMedCrossRefGoogle Scholar
  22. Unger, T., Rascher, W., Schuster, C., Pavlovitch, R., Schomig, A., Dietz, R. and Ganten, D., 1981, Central blood pressure effects of substance P and angiotensin II : Role of the sympathetic nervous system and vasopressin, Eur. J. Pharmacol., 71:33–42.PubMedCrossRefGoogle Scholar
  23. Unger, T., Carolus, S., Demmert, G., Ganten, D., Lang, R.E., Maser-Gluth, C., Steinberg, H. and Veelken, R., 1988, Substance P induces a cardiovascular defense reaction in the rat: Pharmacological characterization, Cir. Res., 63: 812–820.Google Scholar
  24. Wormser, U., Laufer, R., Hart, Y., Chorev, M., Gilon, C. and Selinger, Z., 1986, Highly selective agonists for substance P receptor subtypes, The EMBO J., 5: 2805–2808.Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Hiro-o Kamiya
    • 1
  • Yukio Takano
    • 1
  • Akira Nagashima
    • 1
  1. 1.Department of Pharmacology, Faculty of Pharmaceutical SciencesFukuoka UniversityFukuoka 814-01Japan

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