Regulation of the Nicotinic Acetylcholine Receptor by Serine and Tyrosine Protein Kinases
Neurotransmitter receptors play a central role in the process of signal transduction across synapses between neurons. Neurotransmitters released from the presynaptic neuron diffuse across the synaptic cleft and bind to neurotransmitter receptors in the membrane of the postsynaptic neuron. The neurotransmitter receptors then transduce this signal across the postsynaptic membrane either by directly activating ion channels or by regulating the level of intracellular second messengers in the postsynaptic neuron. Because of the essential role of neurotransmitter receptors in synaptic transmission, the short and long term modulation of neurotransmitter receptor function could be an extremely effective mechanism for the regulation of synaptic plasticity. What are the molecular mechanisms that may be involved in the modulation of neurotransmitter receptor function? Studies on the regulation of cellular metabolism over the past four decades have shown that protein phosphorylation is the primary mechanisms in the regulation of almost all cellular processes (Edelman et al, 1987, Nairn et al, 1985, Hunter et al, 1985).
KeywordsTyrosine Phosphorylation Acetylcholine Receptor Protein Phosphorylation Nicotinic Receptor Nicotinic Acetylcholine Receptor
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