The Nicotinic Acetylcholine Receptor Gene Family: Structure of Nicotinic Receptors from Muscle and Neurons and Neuronal α-Bungarotoxin-Binding Proteins

  • Jon Lindstrom
  • Ralf Schoepfer
  • William Conroy
  • Paul Whiting
  • Manoj Das
  • Mohammad Saedi
  • Rene Anand
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 287)


Three branches of the ligand-gated ion channel gene superfamily encode proteins that bind cholinergic ligands: 1) nicotinic acetylcholine receptors (AChRs) from skeletal muscle, 2) nicotinic AChRs from neurons, and 3) α-bungarotoxin-binding proteins (αBgtBPs) from neurons. AChRs from vertebrate muscles and nerves differ in subunit composition, and in some cases in functional role, but both appear to be formed from several homologous subunits which form ACh-gated cation channels. αBgtBPs from vertebrate neurons have uncertain subunit compositions, uncertain endogenous ligands, and unknown functions. The ligand-gated ion channel gene superfamily also includes receptors for GABA and glycine, which are ligand-gated anion channels, and it probably also includes other ligand-gated ion channels (Barnard et al., 1987; Betz and Becker, 1988). The relation of glutamate receptors to this superfamily is less certain (Gregor et al., 1989; Hollmann et al., 1989; Wada et al., 1989).


Acetylcholine Receptor Nicotinic Acetylcholine Receptor Structural Subunit Chicken Brain Neuronal Nicotinic Acetylcholine Receptor 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Jon Lindstrom
    • 1
  • Ralf Schoepfer
    • 1
  • William Conroy
    • 1
  • Paul Whiting
    • 1
  • Manoj Das
    • 1
  • Mohammad Saedi
    • 1
  • Rene Anand
    • 1
  1. 1.The Salk Institute for Biological StudiesSan DiegoUSA

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