Lipoprotein Structure and Metabolism During Progression and Regression of Atherosclerosis in Pigs Fed With Fish Oil-Derived Fatty Acids

  • A. Van Tol
  • T. Van Gent
  • L. M. Scheek
  • J. E. M. Groener
  • L. M. A. Sassen
  • J. M. J. Lamers
  • P. D. Verdouw
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 285)


Evidence in favor of beneficial effects of dietary fish oil on prevention or regression of atherosclerosis has been obtained from epidemiological studies in man, as well as from experimental studies in pigs (1–5). Both human and animal studies have shown that fish oil-derived fatty acids may have several mechanisms of action, resulting in protection against the atherosclerotic proces. Effects have been described to occur on platelet aggregation (6,7), cytokine synthesis by mononuclear cells (8) and on plasma lipoproteins, especially the very low density lipoproteins (9–13). Some studies show beneficial effects on progression of atherosclerosis even in the absence of significant effects on (extremely elevated) plasma low density lipoprotein (LDL) levels (2,3,14), but a complete analysis of the chemical composition of all lipoprotein classes is lacking. The aim of the present study is to evaluate the concentration and chemical composition of plasma lipoproteins during progression and regression of atherosclerosis, induced by dietary interventions. Plasma cholesterol metabolism by lecithin:cholesterol acyltransferase (LCAT) is also emphasized. Lecithimcholesterol acyltransferase (LCAT) plays a major role in the formation of plasma cholesterylesters. Its activity is crucial for normal plasma cholesterol turnover and a specific function in reverse cholesterol transport (e.g. transport of cholesterol out of the arterial wall to the liver) has been proposed (15).


Bile Acid Cholesterol Acyltransferase Unesterified Cholesterol Lipoprotein Class Plasma Cholesterylesters 
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  1. 1.
    Leaf A, Weber PC (1988) New Engl J Med 318:549–557PubMedCrossRefGoogle Scholar
  2. 2.
    Weiner BH, Ockene IS, Levine PH et al. (1986) New Engl J Med 315:841–846PubMedCrossRefGoogle Scholar
  3. 3.
    Shimokawa H, Vanhoutte PM (1988) Circulation 78:1421–1430PubMedCrossRefGoogle Scholar
  4. 4.
    Kim DN, Ho H-T, Lawrence DA, Schmee J, Thomas WA (1989) Atherosclerosis 76:35–54PubMedCrossRefGoogle Scholar
  5. 5.
    Sassen, LMA, Hartog JM, Lamers JMJ, Klompe M, Van Woerkens LJ, Verdouw PD (1989) Eur Heart J 10:838–846PubMedGoogle Scholar
  6. 6.
    Van Houwelingen AC, Hennissen, AAHM, Verbeek-Schippers F, Simonsen T, Kester ADM, Hornstra G (1988) Thromb Haemostas 59:507–513Google Scholar
  7. 7.
    Hartog JM, Lamers JMJ, Essed CE, Schalkwijk WP, Verdouw PD (1989) Atherosclerosis 76:79–88PubMedCrossRefGoogle Scholar
  8. 8.
    Enders S, Ghorbani R, Kelley VE et al. (1989) New Engl J Med 320:265–271CrossRefGoogle Scholar
  9. 9.
    Harris WS, (1989) J Lipid Res 30:785–807PubMedGoogle Scholar
  10. 10.
    Subbaiah, PV, Davidson MH, Ritter MC, Buchanan W, Bagdade JD (1989) Atherosclerosis 79:157–166PubMedCrossRefGoogle Scholar
  11. 11.
    Sullivan DR, Sanders TAB, Trayner IM, Thompson GR (1986) Atherosclerosis 61:129–134PubMedCrossRefGoogle Scholar
  12. 12.
    Van Houwelingen AC, Zevenbergen, JH, Groot, PHE, Hornstra G (1990) Amer J Clin Nutr, in pressGoogle Scholar
  13. 13.
    Groot PHE, Scheek LM, Dubelaar M-L, Verdouw PD, Hartog JM, Lamers JMJ (1989) Atherosclerosis 77:1–6PubMedCrossRefGoogle Scholar
  14. 14.
    Cahill PD, Sards GE, Cooper AD et al. (1988) J Vase Surg 7:108–118Google Scholar
  15. 15.
    Glomset JA (1968) J Lipid Res 9:155–167PubMedGoogle Scholar
  16. 16.
    Sassen LMA, Hartog JM, Lamers JMJ, Klompe M, Van Woerkens, LJ, Verdouw PD (1989) Europ Heart J 10:838–846Google Scholar
  17. 17.
    Redgrave TG, Roberts DCK, West CE (1975) Anal Biochem 65:42–49PubMedCrossRefGoogle Scholar
  18. 18.
    Van Gent T, Van Tol A (1990) J Chromatography 525:433–441CrossRefGoogle Scholar
  19. 19.
    Glomset JA, Wright JL (1964) Biochim Biophys Acta 89:266–276PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • A. Van Tol
    • 1
  • T. Van Gent
    • 1
  • L. M. Scheek
    • 1
  • J. E. M. Groener
    • 1
  • L. M. A. Sassen
    • 2
  • J. M. J. Lamers
    • 1
  • P. D. Verdouw
    • 2
  1. 1.Department of Biochemistry I, Faculty of Medicine and Health SciencesErasmus University RotterdamRotterdamThe Netherlands
  2. 2.Laboratory for Experimental Cardiology (Thoraxcenter), Faculty of Medicine and Health SciencesErasmus University RotterdamRotterdamThe Netherlands

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