Lipoprotein Structure and Metabolism During Progression and Regression of Atherosclerosis in Pigs Fed With Fish Oil-Derived Fatty Acids
Evidence in favor of beneficial effects of dietary fish oil on prevention or regression of atherosclerosis has been obtained from epidemiological studies in man, as well as from experimental studies in pigs (1–5). Both human and animal studies have shown that fish oil-derived fatty acids may have several mechanisms of action, resulting in protection against the atherosclerotic proces. Effects have been described to occur on platelet aggregation (6,7), cytokine synthesis by mononuclear cells (8) and on plasma lipoproteins, especially the very low density lipoproteins (9–13). Some studies show beneficial effects on progression of atherosclerosis even in the absence of significant effects on (extremely elevated) plasma low density lipoprotein (LDL) levels (2,3,14), but a complete analysis of the chemical composition of all lipoprotein classes is lacking. The aim of the present study is to evaluate the concentration and chemical composition of plasma lipoproteins during progression and regression of atherosclerosis, induced by dietary interventions. Plasma cholesterol metabolism by lecithin:cholesterol acyltransferase (LCAT) is also emphasized. Lecithimcholesterol acyltransferase (LCAT) plays a major role in the formation of plasma cholesterylesters. Its activity is crucial for normal plasma cholesterol turnover and a specific function in reverse cholesterol transport (e.g. transport of cholesterol out of the arterial wall to the liver) has been proposed (15).
KeywordsBile Acid Cholesterol Acyltransferase Unesterified Cholesterol Lipoprotein Class Plasma Cholesterylesters
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