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Antibody-Like Immunoglobulins G Against Low Density Lipoprotein that Stimulate LIPID Accumulation in Cultured Cells

  • Alexander N. Orekhov
  • Vladimir V. Tertov
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 285)

Abstract

Recently, we have found that low density lipoprotein (LDL) derived from the blood of patients with angiographically documented coronary atherosclerosis has an atherogenic potential which manifests itself in cultures of human aortic intimal cells in the accumulation of cellular lipids (mostly free and esterified cholesterol), elevation of proliferative activity and stimulation of extracellular matrix synthesis.1–6 LDL of most healthy donors were devoid of such atherogenic potential. We have established that atherogenic LDL circulating in patients blood is modified lipoprotein differing from nonatherogenic LDL of healthy donors by a low sialic acid content.7 On the other hand, rpinnyai of immunoglobulins C (IgC) fraction from the whole serum of atherosclerotic patients substantially decreased its atherogenic potential.8 We have assumed that the blood serum of atherosclerotic patients contains autoantibodies against modified (desialylated) LDL since the antibodies against LDL can stimulate the accumulation of intracellular cholesterol.9,10

Keywords

Immune Complex Healthy Donor Affinity Constant Cellular Cholesterol Circulate Immune Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Alexander N. Orekhov
    • 1
  • Vladimir V. Tertov
    • 1
  1. 1.Institute of Experimental CardiologyUSSR Cardiology Research CenterMoscowRussia

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