Cholesterol Level in Circulating Immune Complexes as a Marker of Coronary Atherosclerosis

  • Alexander N. Orekhov
  • Oleg S. Kalenich
  • Vladimir V. Tertov
  • Il’ya D. Novikov
  • Elena G. Vorob’eva
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 285)

Abstract

Recently it has been revealed that blood plasma or serum of patients with angiographically assessed coronary atherosclerosis, unlike that of healthy donors, causes lipid accumulation in the cells cultured from human aortic intima. 1,2 This property of serum was termed “atherogenicity” since the accumulation of lipids was paralelled by the stimulation of other atherosclerotic manifestations at the cellular level, namely by increased proliferative activity and synthesis of extracellular matrix.3 Atherogenicity of plasma is accounted for at least two factors: modified (desialylated) low density lipoproteins (LDL) and autoantibodies to LDL which are.formed as a response to the appearance of modified LDL in the blood. 4,5 One may assume that modified LDL and autoantibodies form in blood circulating immune complexes (CIC) underlying atherogenic potential of blood plasma. A simple method was developed to determine the level of LDL component in such complexes. This method is based on the estimation of total cholesterol or apo B in the CIC precipitates obtained as a result of polyeththylene glycol treatment of serum samples. 6,7 Elevated level of CIC cholesterol were more often detected in the serum of patients with angiographically documented coronary atherosclerosis as compared to that of healthy donors.6,7

Keywords

Cholesterol Glycol Triglyceride 

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Alexander N. Orekhov
    • 1
  • Oleg S. Kalenich
    • 1
  • Vladimir V. Tertov
    • 1
  • Il’ya D. Novikov
    • 1
  • Elena G. Vorob’eva
    • 1
  1. 1.USSR Cardiology Research CenterMoscowRussia

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