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Proteoglycans, Lipoproteins, and Atherosclerosis

  • S. R. Srinivasan
  • B. Radhakrishnamurthy
  • P. Vijayagopal
  • G. S. Berenson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 285)

Abstract

Extracellular matrix proteoglycans play an important role in main taining structural integrity and normal function of the arterial wall. These macromolecules provide structural links between fibrous and cellular elements, contribute to viscoelastic properties, regulate permeability and retention of plasma components through the matrix, control vascular cell growth, affect hemostasis and interact with lipoproteins (1,2). These functional properties indicate that proteoglycans are clearly involved in the pathogenesis of atherosclerosis.

Keywords

Chondroitin Sulfate Cholesteryl Ester Sulfate Proteoglycan Dermatan Sulfate Foam Cell Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • S. R. Srinivasan
    • 1
    • 2
  • B. Radhakrishnamurthy
    • 1
    • 2
  • P. Vijayagopal
    • 1
  • G. S. Berenson
    • 1
  1. 1.Department of MedicineLouisiana State University School of MedicineNew OrleansUSA
  2. 2.Department of BiochemistryLouisiana State University School of MedicineNew OrleansUSA

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