Advertisement

The Endocytosis of Lipoproteins by the Liver and their Intracellular Pathway in Comparison to other Ligands

  • Stefan Jäckle
  • Bodo Levkau
  • Thomas Lorenzen
  • Franz Rinninger
  • Wolfgang Daerr
  • Heiner Greten
  • Eberhard Windler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 285)

Abstract

Medizinische Kernklinik und Poliklinik Universitäts-Krankenhaus Eppendorf MartinistraGe 52 D-2000 Hamburg 20, FRG Receptor-mediated endocytosis is well-recognized as a general mechanism used by many cells to take up biologically important molecules. The variety of ligands taken up by receptor-mediated endocytosis includes hormones (e.g. epidermal growth factor (EGF) and insulin), transport proteins carrying nutritional substances (e.g., lipoproteins and transferrin), asialoglycoproteins (ASGPs) and immunoglobulins (Goldstein, Anderson et al. 1979). The terminal catabolism of most plasma lipoproteins and asialoglycoproteins occurs chiefly in the liver by means of receptor-mediated endocytosis (Havel and Hamilton 1988).

Keywords

High Density Lipoprotein Hepatic Uptake Endosomal Membrane Chylomicron Remnant Asialoglycoprotein Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Angelin, B., C. A. Raviola, T. L. Innerarity and R. W. Mahley. (1983). “Regulation of hepatic lipoprotein receptors in the dog; rapid regulation of apolipoprotein B,E receptors, but not of apolipoprotein E receptors, by intestinal lipoproteins and bile acids.”J.CIin.lnvest. 71: 816–831.CrossRefGoogle Scholar
  2. Arbeeny, C. M. and V. A. Rifici. (1984). “The uptake of chylomicron remnants and very low density lipoprotein remnants by the perfused rat liver.”J.Biol.Chem. 259: 9662–9666.PubMedGoogle Scholar
  3. Belcher, J. D., R. L. Hamilton, S. E. Brady, C. A. Hornick, S. Jaeckle, W. J. Schneider and R. J. Havel. (1987). “Isolation and characterization of three endosomal fractions from the liver of estradioltreated rats.”Proc.Natl.Acad.Sci.USA. 84: 6785–6789.PubMedCrossRefGoogle Scholar
  4. Chao, Y. -s., A. L. Jones, G. T. Hradek, E. E. T. Windier and R. J. Havel. (1981). “Autoradiographic localization of the sites of uptake, cellular transport, and catabolism of low density lipoproteins in the liver of normal and estrogen-treated rats.”Proc.Natl.Acad.Sci.USA. 78: 597–601.PubMedCrossRefGoogle Scholar
  5. Dunn, W. A. and A. L. Hubbard. (1984). “Receptor-mediated endocytosis of epidermal growth factor by hepatocytes in the perfused rat liver:ligand and receptor dynamics.”J.Cell Biol. 98: 2148–2159.PubMedCrossRefGoogle Scholar
  6. Dunn, W. A., T. P. Connoly and A. L. Hubbard. (1986). “Receptor-mediated endocytosis of epidermal growth factor by rat hepatocytes:receptor pathway.”J. Cell Biol. 102:24–36.PubMedCrossRefGoogle Scholar
  7. Geuze, H. J., J. W. Slot, G. J. A. M. Strous, H. F. Lodish and A. L. Schwartz. (1983). “Intracellular site of asialoglycoprotein receptor-ligand uncoupling:doublelable immunoelectron microscopy during receptor-mediated endocytosis.”Cell. 32: 277–287.PubMedCrossRefGoogle Scholar
  8. Geuze, H. J., J. W. Slot and A. L. Schwartz. (1987). “Membranes of sorting organelles display lateral heterogeneity in receptor distribution.”J.Cell Biol. 104: 1715–1723.PubMedCrossRefGoogle Scholar
  9. Goldstein, J. L., R. G. W. Anderson and M. S. Brown. (1979). “Coated pits, coated vesicles, and receptor-mediated endocytosis.”Nature. 279: 679–685.PubMedCrossRefGoogle Scholar
  10. Havel, R. J., N. Yamada and D. M. Shames. (1987). “Role of apolipoprotein E in lipoprotein metabolism.”Am.Heart J. 113:470–474.PubMedCrossRefGoogle Scholar
  11. Havel, R. J. and R. L. Hamilton. (1988). “Hepatocytic lipoprotein receptors and intracellular lipoprotein catabolism.”Hepatology. 8: 1689–1704.PubMedCrossRefGoogle Scholar
  12. Jaeckle, S., S. E. Brady and R. J. Havel. (1989). “Membrane binding sites for plasma lipoproteins on endosomes from rat liver.”Proc.Natl.Acad.Sci.USA. 86:1880–1884.PubMedCrossRefGoogle Scholar
  13. Jaeckle, S., S. Miranda-Brady and R. J. Havel. (1990). “Dynamics of epidermal growth factor and its receptor in three hepatic endosomal fractions.”submitted for publication.Google Scholar
  14. Jaeckle, S. and R. J. Havel. (1990). Unpublished dataGoogle Scholar
  15. Jones, A. L, G. T. Hradek, C. Hornick, G. Renaud, E. E. T. Windier and R. J. Havel. (1984). “Uptake and processing of remnants of chylomicrons and very low density lipoproteins by rat liver.”J.Lipid Res. 25: 1151–1158.PubMedGoogle Scholar
  16. Kita, T., J. L. Goldstein, M. S. Brown, Y. Watanabe, C. A. Hornick and R. J. Havel. (1982). “Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor.”Proc.Natl.Acad.Sci.USA. 79: 3623–3627.PubMedCrossRefGoogle Scholar
  17. Lai, W. H., P. H. Cameron, I. Wada, J. -. Doherty, D. G. Kay, B. I. Posner and J. J. M. Bergeron. (1989). “Ligand-mediated internalization, recycling, and downregulation of the epidermal growth factor receptor in vivo.”J.Cell Biol. 109: 2741–2749.PubMedCrossRefGoogle Scholar
  18. Lund, H., K. Takahashi, R. L. Hamilton and R. J. Havel. (1989). “Lipoprotein binding and endosomal itinerary of the low density lipoprotein receptor-related protein in rat liver.”Proc.Natl.Acad.Sci.USA. 86: 9318–9322.PubMedCrossRefGoogle Scholar
  19. Soutar, A. K., K. Harders-Spengel, D. P. Wade and B. L. Knight. (1986). “Detection and quantitation of low density lipoprotein (LDL) receptors in human liver ligand blotting, immunoblotting, and radioimmunoassay; LDL receptor protein content is correlated with plasma LDL cholesterol concentration.”J.Biol.Chem. 261: 17127–17133.PubMedGoogle Scholar
  20. Wall, D. A. and A. L. Hubbard. (1980). “The galactose-specific recognition system of mammalian liver: the route of ligand internalization in rat hepatocytes.”Cell. 21: 79–93.PubMedCrossRefGoogle Scholar
  21. Windier, E., Y. -. Chao and R. J. Havel. (1980a). “Determinants of hepatic uptake of triglyceride-rich lipoproteins and their remnants in the rat.”J.Biol.Chem. 255: 5475–5480.Google Scholar
  22. Windier, E., Y. -. Chao and R. J. Havel. (1980b). “Regulation of the hepatic uptake of triglyceriderich lipoproteins in the rat; opposing effects of homologous apoprotein E and individual C apoproteins.”J.Biol.Chem. 255: 8303–8307.Google Scholar
  23. Windier, E. E. T., P. T. Kovanen, Y. -. Chao, M. S. Brown, R. J. Havel and J. L. Goldstein. (1980). “The estradiol-stimulated lipoprotein receptor of rat liver; a binding site that mediates the uptake of rat lipoproteins containing apoprotein B and E.”J.Biol.Chem. 255(21): 10464–10471.Google Scholar
  24. Windier, E. and R. J. Havel. (1985). “Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver.”J.Lipid Res. 26: 556–565.Google Scholar
  25. Windier, E. E. T., S. Preyer and H. Greten. (1986). “Influence of lysophosphatidylcholine on the Capoprotein content of rat and human triglyceride-rich lipoproteins during triglyceride hydrolysis.”J.CIin.lnvest. 78: 658–665.CrossRefGoogle Scholar
  26. Windier, E. E. T., J. Greeve, W. H. Daerr and H. Greten. (1988). “Binding of rat chylomicrons and their remnants to the hepatic low-density-lipoprotein receptor and its role in remnant removal.”J.Biol.Chem. 252:553–561.Google Scholar
  27. Windier, E., J. Greeve, B. Levkau, V. Kolb-Bachofen, W. Daerr and H. Greten. (1990). “The human asialoglycoprotein-receptor: a possible binding site for LDL and chylomicron remnants.”submitted for publication.Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Stefan Jäckle
    • 1
  • Bodo Levkau
    • 1
  • Thomas Lorenzen
    • 1
  • Franz Rinninger
    • 1
  • Wolfgang Daerr
    • 1
  • Heiner Greten
    • 1
  • Eberhard Windler
    • 1
  1. 1.Medizinische Kernklinik und PoliklinikUniversitäts-Krankenhaus EppendorfHamburg 20Germany

Personalised recommendations