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Recent Advances in Lipoprotein Metabolism and the Genetic Dyslipoproteinemias

  • H. B. BrewerJr.
  • D. J. Rader
  • J. M. Hoeg
  • A. Mann
  • G. Tennyson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 285)

Abstract

During the last two decades major advances have occurred in our understanding of lipoprotein metabolism in normal subjects, and patients with dyslipoproteinemias. Of particular interest has been the elucidation of the role of plasma apolipoproteins, lipoproteins receptors, transfer factors, and lipolytic enzymes in the metabolism of plasma lipoproteins. An improved understanding of the regulation of lipoprotein metabolism, and the intracellular as well as extracellular transport of cholesterol has permitted the determination of molecular defects in patients with dyslipoproteinemias. This new information has been used to development improved methods for diagnosis and treatment of patients at risk for the development of hyperlipidemia and premature cardiovascular disease. This report will summarize recent studies in our laboratory on three apolipoproteins, apoA-I, apoB, and Lp(a).

Keywords

Plasma Lipoprotein Cholesterol Efflux Lipoprotein Metabolism Familial Hypercholesterolemia Lipoprotein Particle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • H. B. BrewerJr.
    • 1
  • D. J. Rader
    • 1
  • J. M. Hoeg
    • 1
  • A. Mann
    • 1
  • G. Tennyson
    • 1
  1. 1.Molecular Disease Branch, National Heart, Lung, and Blood InstituteNational Institutes of HealthBethesdaUSA

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