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What is Meant by Overproduction of Apo B-Containing Lipoproteins?

  • Scott M. Grundy
  • Gloria Lena Vega
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 285)

Abstract

Several mechanisms have been implicated in the development of hyperlipidemia. These include reduced activity of receptors for low density lipoproteins (LDL), deficiencies in lipoprotein lipase (LPL), abnormalities in the primary structures of apolipoproteins C-II, E, and B-100, and overproduction of lipoproteins containing apolipoprotein B-100 (apo B) . All of these except the last are well documented. On the other hand, many researchers believe that overproduction of apo B-containing lipoproteins is one of the more common causes of hyperlipidemia. Therefore, it is worthwhile to consider the evidence for the existence of lipoprotein overproduction as a cause for hyperlipidemia. The present paper will examine the available data related to this question.

Keywords

Fractional Catabolic Rate Familial Combine Hyperlipidemia High Flux Rate Familial Hypertriglyceridemia Primary Hypertriglyceridemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Scott M. Grundy
    • 1
  • Gloria Lena Vega
    • 1
  1. 1.Center for Human Nutrition Departments of Clinical Nutrition Biochemistry and Internal MedicineUniversity of Texas Southwestern Medical Center at DallasDallasUSA

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