Berman’s Simulation Analysis and Modeling

  • Loren A. Zech
  • Daniel J. Rader
  • Peter C. Greif
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 285)


Dr. Mones Berman, whose photograph appears at the beginning of this section, had an enduring interest in the theoretical aspects of lipid, lipoprotein and apolipoprotein metabolism, which stemmed from a more general interest in the systematic analysis of the kinetics and dynamics of metabolic molecules in the biological system. When tracer molecules are used to observe and measure the kinetics of a substance of interest, the obser vations are frequently related to a specific biological models for complete analysis. Possible models should be restricted to those that are compatible with other information about the system. Dr. Berman spent his life developing a formalism for the systematic analysis of tracer data taken from dynamical biological systems in both the steady and changing state.


Numerical Tool Model Diagram Character Description Character Interface Metabolic Molecule 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Berman,M. and Weiss, M.F., 1978 SAAM Manual US DHEW Pub. No. (NIH)75–180. ppl96Google Scholar
  2. 2.
    Berman,M., Beltz,W.F., Greif,P.C, Chaby,R., and Boston,R.C. 1983 CONSAM Users Guide PHS Pub. No. 1983–421–132:3279. U.S. Gov. Printing Office, Washington DC.Google Scholar
  3. 3.
    Berman,M. 1963 The formulation and testing of models. Ann. N. Y. Acad. Sci. 108:182–194PubMedCrossRefGoogle Scholar
  4. 4.
    Berman,M., Shahn,E., and Weiss,M.F. 1962 The routine fitting of kinetic data to models: A mathematical formalism for digital computers. Biophvs. J. 2:275–287CrossRefGoogle Scholar
  5. 5.
    Hall,M., Bilheimer,D., Phair,R., Levy,R., and Berman,M. 1974 A mathematical model for apoprotein kinetics in normal and hyperlipidemic patients. Circulation 50:111–114Google Scholar
  6. 6.
    Blum,C.B., Levy,R.I., Eisenberg,S., Hall,M., Gobel,R.H., and Berman,M. 1977 High density lipoprotein metabolism in man. J. Clin. Invest. 60:795–804PubMedCrossRefGoogle Scholar
  7. 7.
    Zech,L.A., Schaefer,E.J., Osborne,J.C.,Jr., Aamodt,R.L., and Brewer,H.B., Jr. 1984 inetics of Apolipoprotein A-I and A-II. in Pathophysiology of Plasma Protein Metabolism Giulino Mariana, ed., Plenum Publishing Corp., New York.Google Scholar
  8. 8.
    Rader,D.J., Castro,G.R., Kindt,M.R., Zech,L.A., Fruchart, J.C. 1990 Differential in vivo metabolism of HDL subclasses LpA-I and LpA-I,A-II in man. Clin. Res. 38:240A.Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Loren A. Zech
    • 1
    • 2
  • Daniel J. Rader
    • 2
  • Peter C. Greif
    • 1
  1. 1.National Cancer InstituteBethesdaUSA
  2. 2.National Heart Lung and Blood InstituteBethesdaUSA

Personalised recommendations