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Metabolic Role of Human Apoprotein A-IV

  • L. Lagrost
  • P. Gambert
  • A. Athias
  • C. Lallemant
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 285)

Abstract

Compared with the other human apoproteins, physiological variations and metabolic functions of apo A-IV remain obscure. The apo A-IV has been discovered in rat HDL and has been later found in human plasma, mesenteric lymph and interstitial fluid. Apo A-IV is synthetized by intestine and liver and is catabolized by liver and kidneys. As apo A-IV has been suspected to play a role in triglyceride transport, we undertook the study of its plasma concentration in a population of subjects with various plasma triglyceride levels. Moreover, recent studies brought some evidence for an implication of apo A-IV in the reverse cholesterol transport. Because recent reports suggested that HDL was the major lipoprotein class involved in this metabolic pathway, we investigated the structural and metabolic relation between apo A-IV and HDL.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • L. Lagrost
    • 1
  • P. Gambert
    • 1
  • A. Athias
    • 1
  • C. Lallemant
    • 1
  1. 1.Laboratoire de Biochimie des LipoproteinesHôpital du BocageDijon CedexFrance

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