Aldehydic Products of Lipid Peroxidation: Substrates or Inhibitors of Hepatic Aldehyde Dehydrogenase?

  • D. R. Petersen
  • J. J. Hjelle
  • D. Y. Mitchell
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 284)


Peroxidation of membrane lipids is thought be a dynamic process which is ongoing in virtually all cells. Under normal conditions, cellular lipid peroxidation is well regulated and, as noted in a recent review (Esterbauer. et al. , 1990), is always associated with the formation of numerous and chemically diverse aldehydic products. Malondialdehyde (MDA) and trans-4-hydroxy-2-nonenal (HNE) are classified as major products of lipid peroxidation since they are present in the greatest quantities during peroxidation of cellular membrane lipids while trans-2-hexenal, acrolein and crotonaldehdye are representative of minor products of lipid peroxidation thought to be formed in significantly smaller quantities.


Lipid Peroxidation Aldehyde Dehydrogenase ALDH Activity Aldehydic Product Chronic Ethanol Consumption 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • D. R. Petersen
    • 1
  • J. J. Hjelle
    • 1
  • D. Y. Mitchell
    • 1
  1. 1.School of Pharmacy, Alcohol and Hepatobiliary Research CentersUniversity of Colorado Health Sciences CenterDenverUSA

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